Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, Norrköping, 60174, Sweden.
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden.
Adv Healthc Mater. 2023 Sep;12(24):e2300550. doi: 10.1002/adhm.202300550. Epub 2023 Jun 19.
The organic electronic ion pump (OEIP) is an on-demand electrophoretic drug delivery device, that via electronic to ionic signal conversion enables drug delivery without additional pressure or volume changes. The fundamental component of OEIPs is their polyelectrolyte membranes which are shaped into ionic channels that conduct and deliver ionic drugs, with high spatiotemporal resolution. The patterning of these membranes is essential in OEIP devices and is typically achieved using laborious microprocessing techniques. Here, the development of an inkjet printable formulation of polyelectrolyte is reported, based on a custom anionically functionalized hyperbranched polyglycerol (i-AHPG). This polyelectrolyte ink greatly simplifies the fabrication process and is used in the production of free-standing OEIPs on flexible polyimide (PI) substrates. Both i-AHPG and the OEIP devices are characterized, exhibiting favorable iontronic characteristics of charge selectivity and the ability to transport aromatic compounds. Further, the applicability of these technologies is demonstrated by the transport and delivery of the pharmaceutical compound bupivacaine to dorsal root ganglion cells with high spatial precision and effective nerve blocking, highlighting the applicability of these technologies for biomedical scenarios.
有机电子离子泵（OEIP）是一种按需电泳药物输送装置，通过电子到离子信号转换，实现药物输送而无需额外的压力或体积变化。OEIP 的基本组成部分是其聚电解质膜，这些膜被塑造成离子通道，以高时空分辨率输送和传递离子药物。这些膜的图案化是 OEIP 器件中的关键步骤，通常使用繁琐的微加工技术来实现。在这里，报告了一种基于定制阴离子功能化超支化聚甘油（i-AHPG）的聚电解质喷墨打印配方的开发。这种聚电解质墨水极大地简化了制造工艺，并用于在柔性聚酰亚胺（PI）衬底上生产独立式 OEIP。对 i-AHPG 和 OEIP 器件进行了表征，表现出电荷选择性和输送芳香族化合物的能力等有利的离子电子特性。此外，通过将药物化合物布比卡因输送到背根神经节细胞，以高空间精度和有效的神经阻滞，展示了这些技术在生物医学场景中的应用，证明了这些技术的适用性。
