Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, Belgrade, 11000, Serbia.
Curr Pharm Des. 2023;29(12):914-927. doi: 10.2174/1381612829666230413085029.
Flavonoids are secondary metabolites abundantly present in plants and, in most cases, essential contributors to plants bioactivity. They have been studied so far for a range of possible health-beneficial effects, including antioxidant, cardioprotective, and cytotoxic. Therefore, there are data on the antimicrobial potential of a significant number of flavonoids. However, less is known regarding their antivirulence traits. Trending antimicrobial research worldwide has pointed out the promising effects of antimicrobial strategies based on the antivirulence principle, so this review aims to present the newest research regarding the antivirulence effects of flavonoids. Articles on antivirulence flavonoids published from 2015 until now were selected. A range of molecules from this class has been studied up to date, with the most abundant data for quercetin and myricetin, while the most studied organism is Pseudomonas aeruginosa. The antivirulence attributes studied included antibiofilm assessment, followed by data on the inhibition of virulence pigments (pyocyanin, violacein, and staphyloxanthin) and virulence enzyme production (such as sortase A and elastase). Less information is collected on the inhibition of morphological transition, motility, and molecular mechanisms underlying the antivirulence properties of flavonoids and in vivo research. Flavonoids are a group of compounds with a wide range of antivirulence traits and might be further developed into essential parts of novel antimicrobial strategies.
类黄酮是植物中大量存在的次生代谢物，在大多数情况下，是植物生物活性的重要贡献者。迄今为止，它们已经被研究用于一系列可能的健康有益作用，包括抗氧化、心脏保护和细胞毒性。因此，有大量关于许多类黄酮的抗菌潜力的数据。然而，关于它们的抗病毒特性的了解较少。全球趋势的抗菌研究指出了基于抗病毒原理的抗菌策略的有希望的效果，因此，本综述旨在介绍类黄酮的最新抗病毒作用研究。从 2015 年至今发表的关于抗病毒类黄酮的文章被选中。迄今为止，已经研究了这一类的多种分子，其中槲皮素和杨梅素的数据最为丰富，而研究最多的生物体是铜绿假单胞菌。研究的抗病毒属性包括生物膜评估，随后是对抑制毒力色素（绿脓菌素、紫色素和葡萄球菌黄素）和毒力酶产生（如 sortase A 和弹性蛋白酶）的数据。关于抑制形态转变、运动性和类黄酮抗病毒特性的分子机制以及体内研究的信息收集较少。类黄酮是一组具有广泛抗病毒特性的化合物，可能进一步发展成为新型抗菌策略的重要组成部分。
