Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Curr Cancer Drug Targets. 2023;23(10):764-777. doi: 10.2174/1568009623666230413081513.
Colorectal cancer (CRC) is a growing concern worldwide. In recent decades, the incidence of CRC has increased, and this has been attributed to changes in lifestyle. The lack of physical activity, smoking habits, and a diet high in red meat and fat and low in fiber are important aspects of these deleterious changes in lifestyle. The increase in the incidence of CRC has impelled researchers to investigate methods for preventing and treating CRC with greater efficacy and fewer complications. Probiotics are an attractive and potentially promising therapeutic approach. They have been evaluated by a large number of preclinical and clinical studies in recent years, and it has been found that they can play a role in the prevention, treatment, and management of complications of CRC. This review provides a concise summary of the mechanisms of action of probiotics. Furthermore, it focuses on the results of clinical and preclinical studies that evaluated probiotics' effects on CRC management. It also discusses the effects of different strains of probiotics and their combination in CRC treatment.
结直肠癌（CRC）是全球日益关注的问题。近几十年来，CRC 的发病率有所增加，这归因于生活方式的改变。缺乏身体活动、吸烟习惯以及高红肉和高脂肪、低纤维的饮食是这些生活方式有害变化的重要方面。CRC 发病率的增加促使研究人员寻求更有效且并发症更少的方法来预防和治疗 CRC。益生菌是一种有吸引力且有潜力的治疗方法。近年来，大量的临床前和临床研究对其进行了评估，发现它们可以在预防、治疗和管理 CRC 的并发症方面发挥作用。本文综述了益生菌的作用机制，并重点介绍了评估益生菌对 CRC 管理影响的临床和临床前研究结果。还讨论了不同益生菌菌株及其在 CRC 治疗中的联合应用的效果。
