Department of Clinical Medicine, Chongqing Medical University, Chongqing, China.
Nutr Cancer. 2022;74(1):27-38. doi: 10.1080/01635581.2020.1865420. Epub 2020 Dec 24.
In recent years, with the further research on probiotics, probiotics may become an indispensable part in the prevention and treatment of colorectal cancer (CRC) in the future. As one of the most common cancer, the incidence of CRC is still rising in developing countries. Nowadays, there are lacking in prevention methods with low side effect. Surgery and chemotherapy, as the main treatment of CRC, bring many complications and affect the quality of life of patients. Probiotics has provided new ideas to solve these problems. Probiotics have anti-inflammatory, immune-enhancing, tumor-suppressing and other beneficial effects. Probiotics may provide some safe and effective prevention strategies for CRC. In addition, probiotics can also reduce the complications of surgery and chemotherapy, and improve the effectiveness of chemotherapy. Target administration with probiotics or probiotics cooperated with TRAIL to treat CRC. This article aims to review the mechanisms of probiotics for the prevention and treatment of CRC, as well as specific ways to use probiotics, in order to provide more new strategies for the prevention and treatment of CRC in the future, and reduce the incidence of and improve the quality of life of patients.
近年来，随着益生菌研究的进一步深入，益生菌可能成为未来结直肠癌（CRC）防治中不可或缺的一部分。CRC 作为最常见的癌症之一，在发展中国家的发病率仍在上升。目前，缺乏副作用低的预防方法。手术和化疗是 CRC 的主要治疗方法，但会带来许多并发症，影响患者的生活质量。益生菌为解决这些问题提供了新的思路。益生菌具有抗炎、增强免疫、抑制肿瘤等有益作用。益生菌可能为 CRC 提供一些安全有效的预防策略。此外，益生菌还可以减少手术和化疗的并发症，提高化疗的效果。用益生菌或益生菌与 TRAIL 联合进行靶向给药来治疗 CRC。本文旨在综述益生菌防治 CRC 的作用机制，以及益生菌的具体应用方式，以期为 CRC 的防治提供更多新策略，降低发病率，提高患者的生活质量。
