Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of the Ministry of Education of Birth Defects and Related Maternal and Child Diseases, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Int J Gynaecol Obstet. 2023 Oct;163(1):75-88. doi: 10.1002/ijgo.14776. Epub 2023 Apr 17.
Venous thromboembolism (VTE) is one of the primary causes of maternal death. Although many studies have reported maternal VTE, no study has estimated the incidence of it in China.
The aim of this work was to estimate the incidence of maternal VTE in China and to compare the risk factors for it.
The authors searched eight platforms and databases including PubMed, Embase, and Cochrane Library from inception to April 2022, with the search terms "venous thromboembolism" AND "puerperium (pregnancy)" AND "incidence" AND "China."
Studies provide data to calculate the incidence of maternal VTE among Chinese patients.
The authors made a standardized table to collect data and calculated the incidence and 95% confidence intervals (CIs), founding source of heterogeneity by subgroup analysis and meta-regression and judging publication bias by funnel plot and Egger test.
The included 53 papers with a total sample size of 3 813 871 patients had 2539 cases of VTE, and the incidence of maternal VTE in China was 0.13% (95% CI, 0.11-0.16; P < 0.001).
The trend in the incidence of maternal VTE in China is stable. Cesarean section and advanced age are associated with a higher incidence of VTE.
静脉血栓栓塞症（VTE）是导致产妇死亡的主要原因之一。尽管有许多研究报告了产妇 VTE，但没有研究估计中国的 VTE 发病率。
本研究旨在估计中国产妇 VTE 的发病率，并比较其危险因素。
作者检索了从建库至 2022 年 4 月的 8 个平台和数据库，包括 PubMed、Embase 和 Cochrane Library，检索词为“venous thromboembolism”AND“puerperium (pregnancy)”AND“incidence”AND“China”。
研究提供了数据来计算中国患者中产妇 VTE 的发病率。
作者制作了一个标准化表格来收集数据，并计算发病率和 95%置信区间（CI），通过亚组分析和荟萃回归发现异质性来源，并通过漏斗图和 Egger 检验判断发表偏倚。
纳入的 53 篇文献共有 3813871 例患者，其中 2539 例发生 VTE，中国产妇 VTE 的发病率为 0.13%（95%CI，0.11-0.16；P<0.001）。
中国产妇 VTE 的发病率呈稳定趋势。剖宫产和高龄与 VTE 发生率升高相关。
