Laccourreye H, Brasnu D, Menard M, Lacau-St-Guily J, Fabre A, Janot F, Saliba N
Ann Otolaryngol Chir Cervicofac. 1986;103(2):91-103.
On the basis of 642 patients treated and followed up since 1961 at Laennec Hospital, the authors compare the results of radiotherapy, of surgery and of surgery with subsequent radiotherapy. Surgery followed by radiotherapy gives the best 3 and 5 year survival rates and the lowest local and lymph node recurrence rates. The introduction since 1970 of induction chemotherapy shows an improvement in local prognosis and 5 year survival. There has been a more marked improvement since the introduction of cisplatinum and the use of continuous infusions of cisplatinum and of fluoro-5-uracil with or without bleomycin.
基于自1961年以来在拉埃内克医院接受治疗和随访的642例患者，作者比较了放射治疗、手术以及手术联合后续放射治疗的结果。手术联合放射治疗的3年和5年生存率最佳，局部和淋巴结复发率最低。自1970年引入诱导化疗以来，局部预后和5年生存率有所改善。自引入顺铂以及使用顺铂和氟尿嘧啶持续输注（加或不加博来霉素）后，改善更为显著。
