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Isolated Craniocervical Dystonia Without Initial Neuropsychiatric Manifestations Associated with NMDA-Receptor Antibodies.

作者信息

Waller Sophie E, Williams Laura, Lee Adrian Y S, Lin Ming-Wei, McCusker Elizabeth, Morales-Briceño Hugo, Fung Victor S C

机构信息

Movement Disorders Unit, Department of Neurology Westmead Hospital Westmead New South Wales Australia.

Department of Immunology and Immunopathology, Institute of Clinical Pathology and Medical Research Westmead Hospital Westmead New South Wales Australia.

出版信息

Mov Disord Clin Pract. 2022 Aug 9;10(4):680-682. doi: 10.1002/mdc3.13517. eCollection 2023 Apr.

Abstract
摘要

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Glutamate receptor antibodies in neurological diseases: anti-AMPA-GluR3 antibodies, anti-NMDA-NR1 antibodies, anti-NMDA-NR2A/B antibodies, anti-mGluR1 antibodies or anti-mGluR5 antibodies are present in subpopulations of patients with either: epilepsy, encephalitis, cerebellar ataxia, systemic lupus erythematosus (SLE) and neuropsychiatric SLE, Sjogren's syndrome, schizophrenia, mania or stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate blood brain barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and ataxia in animal models, and can be removed or silenced in some patients by immunotherapy.神经疾病中的谷氨酸受体抗体:抗AMPA - GluR3抗体、抗NMDA - NR1抗体、抗NMDA - NR2A/B抗体、抗mGluR1抗体或抗mGluR5抗体存在于以下疾病患者的亚组中:癫痫、脑炎、小脑共济失调、系统性红斑狼疮(SLE)和神经精神性SLE、干燥综合征、精神分裂症、躁狂症或中风。这些自身免疫性抗谷氨酸受体抗体可在少数脑区与神经元结合,激活谷氨酸受体,降低谷氨酸受体的表达,损害谷氨酸诱导的信号传导和功能,激活血脑屏障内皮细胞,杀死神经元,损伤大脑,在动物模型中诱发行为/精神/认知异常和共济失调,并且在一些患者中可通过免疫疗法去除或使其失活。
J Neural Transm (Vienna). 2014 Aug;121(8):1029-75. doi: 10.1007/s00702-014-1193-3. Epub 2014 Aug 1.
7
Psychiatric Presentation of Anti-NMDA Receptor Encephalitis.抗N-甲基-D-天冬氨酸受体脑炎的精神症状表现
Front Neurol. 2019 Nov 5;10:1086. doi: 10.3389/fneur.2019.01086. eCollection 2019.

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