Department of Periodontology, Faculty of Dentistry, Batman University, Batman, Turkey.
Eur Rev Med Pharmacol Sci. 2023 Apr;27(7):2739-2744. doi: 10.26355/eurrev_202304_31901.
Our aim in this study was to investigate the effect of Gallic acid (GA) on gingival tissue injury.
Twenty rats were categorized into two groups. In the burn group, an excisional wound area was created by removing a 4 mm diameter flap from the left molar region in the mucoperiosteal region of the gingiva. In the Burn+gallic acid group, 1.2 mg/ml GA was administered as irrigation for 1 week. Animals were sacrificed under anesthesia at the end of experiment. Malondialdehyde (MDA), myeloperoxidase (MPO) and glutathione (GSH) levels were measured. Hematoxylin Eosin, fibroblast growth factor (FGF) and epidermal growth factor (EGF) immunostaining was applied to tissues.
MDA and MPO levels increased, and GSH, epithelization, FGF and EGF expression levels were decreased. Gallic acid treatment improved these scores. Degenerated gingival epithelium, disintegrity in epithelial and connective tissue fibers, edema and inflammatory cells were observed in the burn group. Gallic acid treatment after burn improved the pathologies. After burn injury, FGF and EGF activity was increased in Gallic acid-treated groups.
We suggest that GA has the potential for better healing outcomes in oral wounds. GA seems to have promising therapeutic efficacy in enhancing oral wound healing.
本研究旨在探讨没食子酸（GA）对牙龈组织损伤的影响。
将 20 只大鼠分为两组。在烧伤组中，通过从牙龈的黏膜骨膜区域的左磨牙区域切除 4 毫米直径的皮瓣来创建切除性伤口区域。在烧伤+没食子酸组中，将 1.2mg/ml 的 GA 作为灌洗液施用 1 周。实验结束时，在麻醉下处死动物。测量丙二醛（MDA）、髓过氧化物酶（MPO）和谷胱甘肽（GSH）水平。对组织进行苏木精和伊红、成纤维细胞生长因子（FGF）和表皮生长因子（EGF）免疫染色。
MDA 和 MPO 水平升高，GSH、上皮化、FGF 和 EGF 表达水平降低。GA 处理改善了这些评分。烧伤组观察到变性的牙龈上皮、上皮和结缔组织纤维的不完整性、水肿和炎症细胞。烧伤后 GA 处理改善了病理学。烧伤后，GA 处理组的 FGF 和 EGF 活性增加。
我们认为 GA 有可能改善口腔伤口的愈合结果。GA 似乎在增强口腔伤口愈合方面具有有前景的治疗效果。
