Department of Internal Medicine, Sakarya University Training and Research Hospital, Sakarya, Turkey.
Eur Rev Med Pharmacol Sci. 2023 Apr;27(7):2808-2814. doi: 10.26355/eurrev_202304_31911.
As an antioxidant and anti-inflammatory agent, Hesperidin was investigated to prove whether it prevents damage to the kidney and lung tissues of rats undergoing renal ischemia-reperfusion injury.
Four groups of rats were set, including eight subjects each as Group 1 (control), Group 2-RIR (renal ischemia reperfusion), Groups 3 and 4 as pretreatment groups (50 HES, 100 HES).
According to our results, Hesperidin pretreatment improved the biochemical and histopathological parameters in kidney and lung tissues of rats with ischemia-reperfusion injury. Besides, a 100 mg/kg dose of Hesperidin was found to be more beneficial to the rats than 50 mg/kg.
The study suggests that Hesperidin is protective against renal and lung tissues of rats that underwent ischemia-reperfusion injury.
作为一种抗氧化剂和抗炎剂，橙皮苷被研究证明是否可以防止肾缺血再灌注损伤大鼠的肾脏和肺组织损伤。
将四组大鼠分为四组，每组 8 只，分别为第 1 组（对照组）、第 2-RIR 组（肾缺血再灌注组）、第 3 组和第 4 组预处理组（50 HES、100 HES）。
根据我们的结果，橙皮苷预处理可改善缺血再灌注损伤大鼠肾和肺组织的生化和组织病理学参数。此外，100mg/kg 剂量的橙皮苷比 50mg/kg 更有益于大鼠。
研究表明，橙皮苷对肾缺血再灌注损伤大鼠的肾脏和肺组织具有保护作用。
