Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Center for Pharmacovigilance and Rational Use of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Eur Rev Med Pharmacol Sci. 2023 Apr;27(7):2832-2844. doi: 10.26355/eurrev_202304_31914.
Hyperuricemia (HUA) is a metabolic disease caused by abnormal purine metabolism in the body. It also shows a trend of high incidence among younger people worldwide. More and more studies have shown that natural products can be used to treat HUA, and the literature in this field has been increasing in recent years. However, few bibliometric analyses have systematically examined this field. Our study aims to analyze the published literature to identify trends and hotspots in natural product therapy for HUA, present the research status and summarize critical topics.
A literature search was conducted through the Web of Science Core Collection (WOSCC) database, using Bibliometric R, VOS Viewer, and CiteSpace to examine the eligible publications. A total of 1,201 publications (1,040 articles and 161 reviews) concerning natural product therapy for HUA research between 2000 and 2021 were ultimately included.
In recent years, research articles in this field have increased. China and the United States are the main driving forces in this field and have a high academic reputation. China published the most relevant articles, while the United States cited the most. Chinese Acad Sci is the institution with the most relevant research results. Flavonoids, xanthine oxidase, antioxidant activity, and gout are the current research hotspots and future research trend topics.
Our results provide a general overview of the leading research directions of natural products in HUA research. The mechanisms of natural products, especially those related to xanthine oxidase, antioxidant activity, and gout, may soon become hot spots and should be closely watched. The field of natural product therapy for HUA is going through rapid development, and our research provides a valuable reference for clinical researchers and practitioners.
高尿酸血症（HUA）是一种由于体内嘌呤代谢异常引起的代谢性疾病。它在全球范围内也呈现出年轻化的发病趋势。越来越多的研究表明，天然产物可用于治疗 HUA，近年来该领域的文献也在不断增加。然而，很少有文献计量分析系统地研究过这个领域。本研究旨在通过对已发表文献进行分析，确定天然产物治疗 HUA 的趋势和热点，呈现研究现状并总结关键议题。
通过 Web of Science Core Collection（WOSCC）数据库进行文献检索，使用 Bibliometric R、VOS Viewer 和 CiteSpace 来检查合格的出版物。最终共纳入 2000 年至 2021 年间关于天然产物治疗 HUA 研究的 1,201 篇文献（1,040 篇文章和 161 篇综述）。
近年来，该领域的研究文章数量有所增加。中国和美国是该领域的主要推动力量，具有较高的学术声誉。中国发表的相关文章最多，而美国的引用量最多。中国科学院是相关研究成果最多的机构。黄酮类化合物、黄嘌呤氧化酶、抗氧化活性和痛风是当前的研究热点和未来的研究趋势议题。
我们的研究结果提供了天然产物在 HUA 研究中主要研究方向的总体概述。天然产物的作用机制，特别是与黄嘌呤氧化酶、抗氧化活性和痛风相关的机制，可能很快成为热点，应密切关注。天然产物治疗 HUA 的领域正在迅速发展，我们的研究为临床研究人员和从业者提供了有价值的参考。
