Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA.
Immunohorizons. 2023 Apr 1;7(4):265-272. doi: 10.4049/immunohorizons.2200010.
IFN-λ or type III IFN is an important mediator of antiviral response. Several respiratory viruses induce the production of IFN-λ during their course of infection. However, they have also developed intricate mechanisms to inhibit its expression and activity. Despite a considerable amount of research on the regulatory mechanisms of respiratory viruses on the IFN-λ response, little is still known about the effect of this cytokine on immune cells and the antiviral effects of all IFN-λ isoforms, and a better understanding of the detrimental effects of IFN-λ treatment is required. Here we highlight the relevance of IFN-λ as an antiviral cytokine in the respiratory tract. Data from studies in vitro, ex vivo, experimental animal models, and ongoing clinical trials emphasize the therapeutic opportunity that IFN-λ represents to treat and prevent different types of respiratory viral infections.
IFN-λ 或 III 型干扰素是抗病毒反应的重要介质。几种呼吸道病毒在感染过程中诱导 IFN-λ 的产生。然而，它们也已经发展出复杂的机制来抑制其表达和活性。尽管已经对呼吸道病毒对 IFN-λ 反应的调控机制进行了大量研究，但对于该细胞因子对免疫细胞的影响以及所有 IFN-λ 同工型的抗病毒作用仍知之甚少，需要更好地了解 IFN-λ 治疗的有害影响。在这里，我们强调了 IFN-λ 作为呼吸道抗病毒细胞因子的相关性。来自体外研究、离体研究、实验动物模型和正在进行的临床试验的数据强调了 IFN-λ 作为治疗和预防不同类型呼吸道病毒感染的治疗机会。
