CTLA4 阻止 T 细胞变装。

Institut Curie , Paris Sciences et Lettres University, Inserm U932, Immunity and Cancer , Paris, France.

Team Integrative Analysis of T Cell Activation , Paris, France.

J Exp Med. 2023 Jul 3;220(7). doi: 10.1084/jem.20230419. Epub 2023 Apr 18.

In this issue of JEM, Xiaozheng Xu et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20221391) report that the inhibitory protein CTLA4 internalizes in cis the B7 stimulatory molecules previously "gnawed" by T cells from antigen-presenting cells (APCs) and in doing so prevents stimulatory T-T interactions.

在本期《实验医学杂志》中，徐小政等人（2023. J. Exp. Med. https://doi.org/10.1084/jem.20221391）报告称，抑制蛋白 CTLA4 在顺式内吞了先前被 T 细胞从抗原呈递细胞（APCs）“吞噬”的 B7 刺激分子，从而阻止了刺激性 T-T 相互作用。