Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Department of Immunology and Genomic Medicine, National Jewish Health, Denver, CO.
J Exp Med. 2021 Jul 5;218(7). doi: 10.1084/jem.20210531. Epub 2021 May 20.
CD1a-autoreactive T cells represent a significant proportion of circulating αβ T cells in humans and appear to be enriched in the skin. How their autoreactivity is regulated remains unclear. In this issue of JEM, Cotton et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20202699) show that CD1a molecules do not randomly survey cellular lipids but instead capture certain lipid classes that broadly interfere with the binding of autoreactive T cell antigen receptors to the target CD1a. These findings provide new potential therapeutic avenues for manipulating CD1a autoreactive T cell responses.
CD1a 自身反应性 T 细胞在人类循环的 αβ T 细胞中占很大比例，似乎在皮肤中更为丰富。其自身反应性如何受到调节尚不清楚。在本期《实验医学杂志》中，Cotton 等人（2021. J. Exp. Med. https://doi.org/10.1084/jem.20202699）表明，CD1a 分子并非随机检测细胞脂质，而是捕获某些脂质类别，这些脂质类别广泛干扰自身反应性 T 细胞抗原受体与靶标 CD1a 的结合。这些发现为操纵 CD1a 自身反应性 T 细胞反应提供了新的潜在治疗途径。
