Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.
Org Lett. 2023 Apr 28;25(16):2767-2770. doi: 10.1021/acs.orglett.3c00571. Epub 2023 Apr 18.
The synthesis of indanes bearing substituted cyanomethyl groups at C2 is achieved through Pd-catalyzed coupling reactions between 2-allylphenyl triflate derivatives and alkyl nitriles. Related partially saturated analogues were generated from analogous transformations of alkenyl triflates. The use of a preformed BrettPhosPd(allyl)(Cl) complex as a precatalyst was essential for the success of these reactions.
通过钯催化 2-烯丙基三氟甲磺酸酯衍生物与烷基腈之间的偶联反应,实现了在 C2 位带有取代氰甲基的茚满的合成。通过类似的烯基三氟甲磺酸酯转化,可以生成相关的部分饱和类似物。使用预形成的 BrettPhosPd(allyl)(Cl)配合物作为前催化剂对于这些反应的成功至关重要。