Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China.
Ren Fail. 2023 Dec;45(1):2169617. doi: 10.1080/0886022X.2023.2169617.
The effects of serum uric acid (SUA) on clinical outcomes in patients with acute kidney injury (AKI) are unclear. The aim of this study was to investigate the association of SUA levels with clinical outcomes of AKI patients.
The data of AKI patients hospitalized in the Affiliated Hospital of Qingdao University were retrospectively reviewed. Multivariable logistic regression was utilized to assess the association between SUA levels and the clinical outcomes of AKI patients. Receiver operating characteristic (ROC) analysis was applied to assess the predictive ability of SUA levels for in-hospital mortality in patients with AKI.
A total of 4,646 AKI patients were eligible for study inclusion. In multivariable analysis, after adjustment for various confounding factors in the fully adjusted model, a higher SUA level was found to be associated with increased in-hospital mortality of AKI patients with an odds ratio (OR) of 1.72 (95% CI, 1.21-2.33, = 0.005) for the SUA level >5.1-6.9 mg/dl group and 2.75 (95% CI, 1.78-4.26, < 0.001) for the SUA level >6.9 mg/dl group compared with the reference group (SUA ≤3.6 mg/dl). In the ROC analysis, the area under the curve (AUC) of SUA was 0.65 with a sensitivity of 51% and a specificity of 73%.
An elevated SUA level is associated with an increased risk of in-hospital mortality in patients with AKI, and it appears to be an independent prognostic marker for these patients.
血清尿酸（SUA）对急性肾损伤（AKI）患者临床结局的影响尚不清楚。本研究旨在探讨 SUA 水平与 AKI 患者临床结局的关系。
回顾性分析青岛大学附属医院 AKI 患者的临床资料。采用多变量 logistic 回归评估 SUA 水平与 AKI 患者临床结局的关系。采用受试者工作特征（ROC）曲线分析评估 SUA 水平对 AKI 患者住院死亡率的预测能力。
共纳入 4646 例 AKI 患者。多变量分析显示，在校正全模型中的各种混杂因素后，较高的 SUA 水平与 AKI 患者住院死亡率增加相关，SUA 水平>5.1-6.9 mg/dl 组的比值比（OR）为 1.72（95%CI，1.21-2.33，=0.005），SUA 水平>6.9 mg/dl 组的 OR 为 2.75（95%CI，1.78-4.26，<0.001），与参考组（SUA≤3.6 mg/dl）相比。在 ROC 分析中，SUA 的曲线下面积（AUC）为 0.65，灵敏度为 51%，特异度为 73%。
SUA 水平升高与 AKI 患者住院死亡率增加相关，SUA 可能是预测 AKI 患者预后的独立标志物。
