Paukov V S
Arkh Patol. 1986;48(3):30-8.
Early stages of bordering the focus of purulent and aseptic inflammation in man and in experimental animals are studied with a particular analysis of the role of polynuclear neutrophils (PNN) and macrophages (MP) in this process. Two variants of a purulent inflammation are studied: widespread diffuse (peritonitis) and circumscribed (abscess). Aseptic diffuse peritonitis and circuscribed inflammation of muscles are studied as control. Methods of light and electron microscopy are used. It is shown that in a purulent and aseptic inflammation a phylogenetically predetermined reaction develops which is directed to the localization and limitation of an inflammatory focus. This response is brought about by blood cells--PNN and MP--between which an interconnection exists stipulated by their function. PNN are the first to appear in the inflammatory focus and their main function is to reveal the presence or the absence of the infection, localization and destruction of bacteria. Macrophages appear in the inflammatory focus later, their function is in the circumscription of the focus and in the stimulation of the connective tissue capsula around the purulent zone or the development of scar in the aseptic inflammation.
对人类和实验动物中脓性和无菌性炎症病灶边界的早期阶段进行了研究，并特别分析了多核中性粒细胞（PNN）和巨噬细胞（MP）在此过程中的作用。研究了脓性炎症的两种变体：广泛弥漫性（腹膜炎）和局限性（脓肿）。将无菌性弥漫性腹膜炎和肌肉局限性炎症作为对照进行研究。使用了光学显微镜和电子显微镜方法。结果表明，在脓性和无菌性炎症中会发生一种系统发育预先确定的反应，该反应旨在定位和限制炎症病灶。这种反应是由血细胞——PNN和MP——引起的，它们之间存在由其功能规定的相互联系。PNN最先出现在炎症病灶中，其主要功能是发现感染的存在与否、细菌的定位和破坏。巨噬细胞稍后出现在炎症病灶中，其功能是限制病灶，并刺激脓性区域周围的结缔组织包膜形成，或在无菌性炎症中促进瘢痕形成。
