Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Key Lab of Modern Separation Science in Shaanxi Province, College of Chemistry and Materials Science, Northwest University, Xi'an, Shaanxi 710127, P. R. China.
Shaanxi Provincial Key Laboratory of Biotechnology, Joint International Research Laboratory of Glycobiology and Medicinal Chemistry, College of Life Science, Northwest University, Xi'an, Shaanxi 710127, P. R. China.
Anal Chem. 2023 May 2;95(17):6931-6939. doi: 10.1021/acs.analchem.3c00230. Epub 2023 Apr 19.
Delayed wound healing is one of the major diabetes complications that occur in 25% of diabetic patients. Specific wound management and combination treatment are required to repair the wound, which still remains a challenge with few effective therapies available currently. In this work, a new HS donor , which is characterized by the capability to promote wound healing in diabetes, was designed. can be activated by light without consuming endogenous substances and the accompanying fluorescent signal makes the real-time tracking of released HS possible. is able to deliver HS in an intracellular environment with moderate release efficiency (50%), which presents cytoprotective effects against excessive reactive oxygen species (ROS) induced damage. Furthermore, the potential of to enhance chronic wound healing was validated by employing diabetic models. This work provides new insights into the therapeutic role of HS donors in complex wound conditions, which should advance the pathophysiological research associated with HS.
延迟性伤口愈合是糖尿病的主要并发症之一，25%的糖尿病患者会发生这种并发症。需要特定的伤口管理和联合治疗来修复伤口，但目前可用的有效治疗方法很少，这仍然是一个挑战。在这项工作中，设计了一种新的 HS 供体，其特点是能够促进糖尿病患者的伤口愈合。可以在不消耗内源性物质的情况下被光激活，并且伴随的荧光信号使得 HS 的实时跟踪成为可能。能够在细胞内环境中以中等释放效率（50%）输送 HS，对过量的活性氧（ROS）诱导的损伤表现出细胞保护作用。此外，通过使用糖尿病模型验证了 对慢性伤口愈合的增强作用。这项工作为 HS 供体在复杂伤口条件下的治疗作用提供了新的见解，这将推动与 HS 相关的病理生理学研究。
