Lu Huangjie, Zeng Huiying, Wei Wenlong, Chen Yuying, Zhou Ziqiang, Ning Xuyang, Hu Ping
Department of Burns & Plastic Surgery, Guangzhou Red Cross Hospital, Faculty of Medical Science, Jinan University, Guangzhou 510006, China.
College of Pharmacy, Jinan University, Guangzhou 510006, China.
Theranostics. 2024 Nov 4;14(19):7589-7603. doi: 10.7150/thno.100930. eCollection 2024.
Cerebral ischemia-reperfusion injury is a severe neurovascular disease that urgently requires effective therapeutic interventions. Recently, hydrogen sulfide (HS) has garnered significant attention as a potential treatment for stroke; however, the precise and targeted delivery of HS remains a considerable challenge for its clinical application. We have developed HSDF-NH, a novel HS donor characterized by high selectivity, self-reporting capabilities, and the ability to penetrate the blood-brain barrier (BBB). HSDF-NH effectively scavenges reactive oxygen species (ROS) while generating HS, with emitted fluorescence facilitating the visualization and quantification of HS release. This compound has demonstrated protective effects against cerebral ischemia-reperfusion (I/R) injury and contributes to the reconstruction of brain structure and function in a rat stroke model (tMCAO/R). As a ROS-responsive, self-reporting, and fluorescent HS donor, HSDF-NH holds considerable promise for the treatment of ischemic diseases beyond stroke.
脑缺血再灌注损伤是一种严重的神经血管疾病，迫切需要有效的治疗干预措施。最近，硫化氢（HS）作为中风的潜在治疗方法受到了广泛关注；然而，HS的精确靶向递送仍然是其临床应用面临的一个重大挑战。我们开发了HSDF-NH，这是一种新型的HS供体，具有高选择性、自我报告能力以及穿透血脑屏障（BBB）的能力。HSDF-NH在产生HS的同时有效清除活性氧（ROS），发出的荧光有助于可视化和定量HS的释放。该化合物已在大鼠中风模型（tMCAO/R）中显示出对脑缺血再灌注（I/R）损伤的保护作用，并有助于脑结构和功能的重建。作为一种ROS响应、自我报告且具有荧光的HS供体，HSDF-NH在治疗中风以外的缺血性疾病方面具有很大的潜力。
