McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Ontario K1G 5Z3, Canada.
School of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario K1G 5Z3, Canada.
Toxicol Sci. 2023 Jun 28;194(1):13-22. doi: 10.1093/toxsci/kfad039.
A series of recent and proposed workshops address the interface between key characteristics and mechanistic pathway descriptions (adverse outcome pathways and mode of action) to identify commonalities and potential for complementary application. Informed by different communities, these constructs have collective potential to increase confidence to support the application of mechanistic data in hazard assessment. This forum article summarizes concepts, introduces evolving understanding, and invites future collaboration to contribute to better common understanding and development of good practice in the use of mechanistic data in hazard assessment.
一系列最近和拟议的研讨会探讨了关键特征与机制途径描述（不良结局途径和作用模式）之间的接口，以确定共性和互补应用的潜力。这些构建体受到不同社区的启发，具有提高支持将机制数据应用于危害评估的信心的集体潜力。本文论坛总结了概念，介绍了不断发展的认识，并邀请未来的合作，以促进更好的共同理解和发展在危害评估中使用机制数据的良好实践。
