National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Huaxi District, Guiyang 550025, China.
Key Laboratory of Agri-Food Safety of Anhui Province, School of Resources and Environment, Anhui Agricultural University, Hefei 230036, China.
J Agric Food Chem. 2023 May 3;71(17):6561-6569. doi: 10.1021/acs.jafc.2c08880. Epub 2023 Apr 19.
A series of isoxazoline derivatives containing diacylhydrazine moieties were designed and synthesized as potential insecticides. Most of these derivatives exhibited good insecticidal activities against , and some compounds exhibited excellent insecticidal activities against . Especially, showed outstanding insecticidal activity against (LC = 0.37 μg/mL), which was superior to that of ethiprole (LC = 2.84 μg/mL) and tebufenozide (LC = 15.3 μg/mL) and similar to that of fluxametamide (LC = 0.30 μg/mL). Remarkably, the insecticidal activity of against (LC = 1.72 μg/mL) was superior to that of chlorantraniliprole (LC = 3.64 μg/mL) and tebufenozide (LC = 60.5 μg/mL) but lower than that of fluxametamide (LC = 0.14 μg/mL). The results of electrophysiological experiments, molecular docking, and proteomics experiments indicate that compound acts by interfering with the γ-aminobutyric acid receptor to control pests.
一系列含有二酰肼部分的异恶唑啉衍生物被设计和合成，作为潜在的杀虫剂。这些衍生物大多数对表现出良好的杀虫活性，一些化合物对表现出优异的杀虫活性。特别是对（LC=0.37μg/mL）表现出突出的杀虫活性，优于乙虫腈（LC=2.84μg/mL）和虫酰肼（LC=15.3μg/mL），与氟虫酰胺（LC=0.30μg/mL）相当。值得注意的是，对（LC=1.72μg/mL）的杀虫活性优于氯虫苯甲酰胺（LC=3.64μg/mL）和虫酰肼（LC=60.5μg/mL），但低于氟虫酰胺（LC=0.14μg/mL）。电生理实验、分子对接和蛋白质组学实验的结果表明，化合物通过干扰γ-氨基丁酸受体来控制害虫。
