Giresun University, Faculty of Medicine, Department of Physical Therapy and Rehabilitation - Giresun, Turkey.
Giresun University, Faculty of Medicine, Department of Endocrinology - Giresun, Turkey.
Rev Assoc Med Bras (1992). 2023 Apr 14;69(4):e20221615. doi: 10.1590/1806-9282.20221615. eCollection 2023.
Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis or autoimmune thyroiditis, is a considerable part of the spectrum of chronic autoimmune thyroid gland disorders which is pathologically associated with various degrees of lymphocytic infiltration. The purpose of the present study was to evaluate whether cartilage thickness is affected in patients with Hashimoto's thyroiditis or not in thyroidology.
A total of 61 individuals had been evaluated in this case-control study, including 32 euthyroid Hashimoto's thyroiditis patients and 29 healthy subjects comparable in age, sex, and body mass index. The patients with a history of knee trauma or knee surgery, an additional systemic disease such as diabetes mellitus, or an inflammatory disease like rheumatoid arthritis, systemic lupus erythematosus, and scleroderma had not been included in the study. The thickness of the femoral articular cartilage was measured using B-mode ultrasonography, and the right lateral condyle, right intercondylar area, right medial condyle, left medial condyle, left intercondylar area, and left lateral condyle were also measured.
No statistically significant difference between patients with Hashimoto's thyroiditis diagnosis and healthy controls in terms of age, age groups, gender, and body mass index (p>0.05).
As a consequence, no obvious connection between autoimmune markers and cartilage thickness in patients with Hashimoto's thyroiditis was recognized. Although the diverse manifestation of Hashimoto's thyroiditis could be observed, it seems to be no liaison between thyroid autoimmunity and cartilage thickness.
桥本甲状腺炎,亦称慢性淋巴细胞性甲状腺炎或自身免疫性甲状腺炎,是慢性自身免疫性甲状腺疾病谱中的重要组成部分,其病理表现与不同程度的淋巴细胞浸润相关。本研究旨在评估桥本甲状腺炎患者的甲状腺功能是否会影响软骨厚度。
本病例对照研究共纳入 61 名参与者,包括 32 名甲状腺功能正常的桥本甲状腺炎患者和 29 名年龄、性别和体重指数相匹配的健康对照者。本研究排除了有膝关节外伤或膝关节手术史、合并糖尿病等其他系统性疾病或类风湿关节炎、系统性红斑狼疮、硬皮病等炎性疾病的患者。采用 B 型超声测量股关节软骨的厚度,测量右侧外侧髁、右侧髁间区、右侧内侧髁、左侧内侧髁、左侧髁间区和左侧外侧髁。
桥本甲状腺炎患者与健康对照组在年龄、年龄组、性别和体重指数方面无统计学差异(p>0.05)。
因此,桥本甲状腺炎患者的自身免疫标志物与软骨厚度之间没有明显的关联。尽管桥本甲状腺炎的表现多种多样,但甲状腺自身免疫与软骨厚度之间似乎没有联系。