桥本甲状腺炎在就诊于三级护理中心的甲状腺疾病患者中的发病率。

Hashimoto's Thyroiditis among Patients with Thyroid Disorders Visiting a Tertiary Care Centre.

机构信息

Department of Internal Medicine, Metro Kathmandu Hospital, Maharajgunj, Kathmandu, Nepal.

Nepal Medical College and Teaching Hospital, Jorpati, Kathmandu, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2023 Aug 1;61(264):630-632. doi: 10.31729/jnma.8236.

DOI:10.31729/jnma.8236

PMID:38289816

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10566609/

Abstract

INTRODUCTION

Hashimoto's thyroiditis is a chronic autoimmune lymphocytic thyroiditis characterised by thyroid autoantibodies. Early detection and treatment of this condition help in reducing the morbidity and mortality associated with it. The aim of the study was to find out the prevalence of Hashimoto's thyroiditis among patients with thyroid disorders visiting a tertiary care centre.

METHODS

A descriptive cross-sectional study was conducted among patients visiting the outpatient department of a tertiary care centre. Data from 14 April 2017 to 13 April 2019 was collected between 30 June 2022 to 15 September 2022 from medical records. Ethical approval was obtained from the Nepal Health Research Council. Hashimoto's thyroiditis was diagnosed based on clinical presentation and positive antibodies to thyroid antigens. Convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval.

RESULTS

Among 813 patients with thyroid disorders, 393 (48.33%) (44.89-51.77, 95% Confidence Interval) had Hashimoto's thyroiditis. The manifestation of the spectrum of Hashimoto's thyroiditis were euthyroid in 215 (54.70%), subclinical hypothyroidism in 102 (25.95%), subclinical hyperthyroidism in 23 (5.85%), overt hyperthyroidism in 9 (2.30%) and overt hypothyroidism in 4 (1.02%).

CONCLUSIONS

The prevalence of Hashimoto's thyroiditis among patients with thyroid disorders was higher than in other studies done in similar settings.

KEYWORDS

anti-thyroid peroxidase antibodies; Hashimoto's thyroiditis; thyroid disorders.

摘要

简介

桥本甲状腺炎是一种慢性自身免疫性淋巴细胞性甲状腺炎，其特征是存在甲状腺自身抗体。早期发现和治疗这种疾病有助于降低与之相关的发病率和死亡率。本研究的目的是了解在一家三级保健中心就诊的甲状腺疾病患者中桥本甲状腺炎的患病率。

方法

对一家三级保健中心的门诊患者进行了描述性横断面研究。2022 年 6 月 30 日至 2022 年 9 月 15 日期间，从病历中收集了 2017 年 4 月 14 日至 2019 年 4 月 13 日的数据。本研究获得了尼泊尔健康研究委员会的伦理批准。桥本甲状腺炎的诊断基于临床表现和甲状腺抗原抗体阳性。采用便利抽样法。点估计值在 95%置信区间计算。

结果

在 813 例甲状腺疾病患者中，有 393 例（48.33%）（44.89-51.77，95%置信区间）患有桥本甲状腺炎。桥本甲状腺炎谱的表现为：甲状腺功能正常 215 例（54.70%）、亚临床甲状腺功能减退 102 例（25.95%）、亚临床甲状腺功能亢进 23 例（5.85%）、显性甲状腺功能亢进 9 例（2.30%）和显性甲状腺功能减退 4 例（1.02%）。