Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Universidade de Uberaba, Uberaba, MG, Brazil.
Einstein (Sao Paulo). 2023 Apr 17;21:eAO0230. doi: 10.31744/einstein_journal/2023AO0230. eCollection 2023.
• No drug related fetal malformations. • No adverse effects on vital organ functions. To assess the effects of enfuvirtide on pregnancy in albino rats and their fetuses.
Forty pregnant EPM 1 Wistar rats were randomly allocated into four groups: control (E) (distilled water twice/day), G1 (4mg/kg/day enfuvirtide), G2 (12mg/kg/day enfuvirtide), and G3 (36mg/kg/day enfuvirtide) groups. On the 20th day of gestation, the rats were anesthetized and subjected to cesarean section. Their blood was collected for laboratory analysis, and they were sacrificed. The offspring's fragments of their kidneys, liver, and placentas and the maternal rats' fragments of their lungs, kidneys, and liver were separated in the immediate postpartum period for light microscopy analysis.
No maternal deaths occurred. In the second week at the end of pregnancy, the mean weight of the G3 Group was significantly lower than that of the G2 Group (p=0.029 and p=0.028, respectively). Analyzing blood laboratory parameters, the G1 Group had the lowest mean amylase level, and the G2 Group had the lowest mean hemoglobin level and the highest mean platelet count. In the morphological analysis, there were no changes in organs, such as the kidneys and liver, in both the maternal rats and offspring. Three maternal rats in the G3 Group had pulmonary inflammation in the lungs.
Enfuvirtide has no significant adverse effects on pregnancy, conceptual products, or functional alterations in maternal rats.
无药物相关的胎儿畸形。
对重要器官功能无不良影响。
评估恩夫韦肽对白化孕鼠及其胎儿的影响。
将 40 只怀孕的 EPM 1 Wistar 大鼠随机分为四组：对照组（E）（每天两次给予蒸馏水）、G1 组（4mg/kg/天恩夫韦肽）、G2 组（12mg/kg/天恩夫韦肽）和 G3 组（36mg/kg/天恩夫韦肽）。在妊娠第 20 天，对大鼠进行麻醉并进行剖腹产。采集其血液进行实验室分析，并进行安乐死。产后立即分离其子代肾脏、肝脏和胎盘的碎片以及母鼠的肺、肾脏和肝脏的碎片，进行光镜分析。
未发生母体死亡。在妊娠结束后的第二周，G3 组的平均体重明显低于 G2 组（分别为 p=0.029 和 p=0.028）。分析血液实验室参数，G1 组的平均淀粉酶水平最低，G2 组的平均血红蛋白水平最低，平均血小板计数最高。在形态学分析中，母鼠和子代的肾脏和肝脏等器官均无变化。G3 组的 3 只母鼠的肺部有炎症。
恩夫韦肽对妊娠、胎儿或母鼠的功能改变无明显不良影响。
