• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在经大量治疗的围产期感染孕妇中使用含达芦那韦、依曲韦林、拉替拉韦或恩夫韦肽的挽救治疗方案。

Salvage Regimens Containing Darunavir, Etravirine, Raltegravir, or Enfuvirtide in Highly Treatment-Experienced Perinatally Infected Pregnant Women.

作者信息

Shust Gail F, Jao Jennifer, Rodriguez-Caprio Gabriela, Posada Roberto, Chen Katherine T, Averitt Amelia, Sperling Rhoda S

机构信息

Department of Pediatrics.

Department of Medicine, and.

出版信息

J Pediatric Infect Dis Soc. 2014 Sep;3(3):246-50. doi: 10.1093/jpids/pit019. Epub 2013 Apr 12.

DOI:10.1093/jpids/pit019
PMID:25844164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4381746/
Abstract

Combination antiretroviral therapy in pregnant women with human immunodeficiency virus has dramatically decreased maternal-to-child transmission. Highly treatment-experienced pregnant patients have limited effective treatment options due to past toxicities and viral resistance. We present 8 pregnancies in 7 perinatally infected women successfully treated with salvage regimens containing darunavir, etravirine, raltegravir, or enfuvirtide.

摘要

对感染人类免疫缺陷病毒的孕妇采用抗逆转录病毒联合疗法已显著降低了母婴传播率。由于既往出现的毒性反应和病毒耐药性，有丰富治疗经验的孕妇有效治疗选择有限。我们报告了7名围产期感染女性的8次妊娠情况，她们成功接受了含达芦那韦、依曲韦林、拉替拉韦或恩夫韦肽的挽救治疗方案。

相似文献

1
Salvage Regimens Containing Darunavir, Etravirine, Raltegravir, or Enfuvirtide in Highly Treatment-Experienced Perinatally Infected Pregnant Women.在经大量治疗的围产期感染孕妇中使用含达芦那韦、依曲韦林、拉替拉韦或恩夫韦肽的挽救治疗方案。
J Pediatric Infect Dis Soc. 2014 Sep;3(3):246-50. doi: 10.1093/jpids/pit019. Epub 2013 Apr 12.
2
Novel antiretroviral combinations in treatment-experienced patients with HIV infection: rationale and results.新型抗逆转录病毒联合疗法在治疗经验丰富的 HIV 感染患者中的应用：原理和结果。
Drugs. 2010 Sep 10;70(13):1629-42. doi: 10.2165/11538020-000000000-00000.
3
Raltegravir dosage adjustment in HIV-infected patients receiving etravirine.依曲韦林治疗的 HIV 感染者中拉替拉韦的剂量调整。
Am J Health Syst Pharm. 2011 Nov 1;68(21):2049-54. doi: 10.2146/ajhp110083.
4
Use of newer antiretroviral agents, darunavir and etravirine with or without raltegravir, in pregnancy: a report of two cases.新型抗逆转录病毒药物达芦那韦和依曲韦林联合或不联合雷特格韦在妊娠期的应用：两例报告
Antivir Ther. 2010;15(4):677-80. doi: 10.3851/IMP1558.
5
Raltegravir: new Drug. Alternative to enfuvirtide/darunavir in multidrug-resistant HIV.拉替拉韦：新药。用于多重耐药HIV的恩夫韦肽/达芦那韦替代药物。
Prescrire Int. 2008 Aug;17(96):135-7.
6
Drug susceptibility to etravirine and darunavir among Human Immunodeficiency Virus Type 1-derived pseudoviruses in treatment-experienced patients with HIV/AIDS in South Korea.韩国接受过治疗的HIV/AIDS患者中，1型人类免疫缺陷病毒衍生的假病毒对依曲韦林和达芦那韦的药物敏感性。
Virol J. 2015 Apr 9;12:53. doi: 10.1186/s12985-015-0283-7.
7
High rate of virologic suppression with raltegravir plus etravirine and darunavir/ritonavir among treatment-experienced patients infected with multidrug-resistant HIV: results of the ANRS 139 TRIO trial.在感染多重耐药HIV的经治患者中，雷特格韦联合依曲韦林及达芦那韦/利托那韦治疗的病毒学抑制率较高：ANRS 139 TRIO试验结果
Clin Infect Dis. 2009 Nov 1;49(9):1441-9. doi: 10.1086/630210.
8
Efficacy, safety, and tolerability of etravirine with and without darunavir/ritonavir or raltegravir in treatment-experienced patients: analysis of the etravirine early access program in the United States.依曲韦林在有或无达芦那韦/利托那韦或雷特格韦治疗经治患者中的疗效、安全性和耐受性：美国依曲韦林早期准入计划分析。
J Acquir Immune Defic Syndr. 2010 Apr;53(5):614-8. doi: 10.1097/QAI.0b013e3181cdebb1.
9
Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pre-treated HIV-infected patients.在经过大量治疗的 HIV 感染患者中，雷特格韦、达芦那韦、依曲韦林和利托那韦的细胞内和血浆稳态药代动力学。
Br J Clin Pharmacol. 2010 May;69(5):475-83. doi: 10.1111/j.1365-2125.2010.03634.x.
10
Use of new antiretroviral drugs and classes in Bahia, Brazil: a real life experience on salvage therapy of AIDS patients.巴西巴伊亚州新型抗逆转录病毒药物及其类别应用：艾滋病患者挽救治疗的真实经验
Braz J Infect Dis. 2015 Sep-Oct;19(5):529-32. doi: 10.1016/j.bjid.2015.03.005. Epub 2015 May 19.

引用本文的文献

1
Action of enfuvirtide on the pregnancy of albino rats ( Rattus norvegicus albinus, Rodentia, Mammalia ): biological assay and functional and histological analyses of exposed maternal-fetal organs.恩夫韦肽对白化孕鼠（ Rattus norvegicus albinus ，啮齿目，哺乳纲）妊娠的作用：暴露于母胎器官的生物测定及功能和组织学分析。
Einstein (Sao Paulo). 2023 Apr 17;21:eAO0230. doi: 10.31744/einstein_journal/2023AO0230. eCollection 2023.
2
A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses.一种基于肽的病毒灭活剂可抑制怀孕小鼠及其胎儿感染寨卡病毒。
Nat Commun. 2017 Jul 25;8:15672. doi: 10.1038/ncomms15672.
3
Etravirine Pharmacokinetics in HIV-Infected Pregnant Women.依曲韦林在感染HIV的孕妇中的药代动力学。
Front Pharmacol. 2016 Aug 4;7:239. doi: 10.3389/fphar.2016.00239. eCollection 2016.
4
Integrase inhibitors in late pregnancy and rapid HIV viral load reduction.妊娠晚期的整合酶抑制剂与HIV病毒载量的快速降低
Am J Obstet Gynecol. 2016 Mar;214(3):385.e1-7. doi: 10.1016/j.ajog.2015.12.052.

本文引用的文献

1
Laboratory Abnormalities Among HIV-Exposed, Uninfected Infants: IMPAACT Protocol P1025.暴露于HIV但未感染的婴儿的实验室异常情况：IMPAACT方案P1025。
J Pediatric Infect Dis Soc. 2012 Jun;1(2):92-102. doi: 10.1093/jpids/pis036. Epub 2012 May 3.
2
Raltegravir in pregnancy: a case series presentation.孕期使用雷特格韦：病例系列报告
Int J STD AIDS. 2011 Jun;22(6):358-60. doi: 10.1258/ijsa.2011.010469.
3
Safety and pharmacokinetics of etravirine in pregnant HIV-1-infected women.依曲韦林在感染HIV-1的孕妇中的安全性和药代动力学。
HIV Med. 2011 Apr;12(4):257-8. doi: 10.1111/j.1468-1293.2010.00874.x.
4
High neonatal concentrations of raltegravir following transplacental transfer in HIV-1 positive pregnant women.在HIV-1阳性孕妇中经胎盘转移后新生儿体内拉替拉韦浓度较高。
AIDS. 2010 Sep 24;24(15):2416-8. doi: 10.1097/QAD.0b013e32833d8a50.
5
Use of darunavir/ritonavir once daily in treatment-naive pregnant woman: pharmacokinetics, compartmental exposure, efficacy and safety.初治孕妇每日一次使用达芦那韦/利托那韦：药代动力学、房室暴露、疗效及安全性
AIDS. 2010 Apr 24;24(7):1083-4. doi: 10.1097/QAD.0b013e32833653b2.
6
Successful use of darunavir, etravirine, enfuvirtide and tenofovir/emtricitabine in pregnant woman with multiclass HIV resistance.达芦那韦、依曲韦林、恩夫韦肽和替诺福韦/恩曲他滨在多类别HIV耐药孕妇中的成功应用。
AIDS. 2009 Jan 28;23(3):434-5. doi: 10.1097/QAD.0b013e32832027d6.
7
Combination antiretroviral strategies for the treatment of pregnant HIV-1-infected women and prevention of perinatal HIV-1 transmission.用于治疗感染HIV-1的孕妇及预防围产期HIV-1传播的联合抗逆转录病毒策略。
J Acquir Immune Defic Syndr. 2002 Apr 15;29(5):484-94. doi: 10.1097/00126334-200204150-00009.
8
Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.母亲的病毒载量、齐多夫定治疗与人类免疫缺陷病毒1型母婴传播风险。儿童艾滋病临床试验组方案076研究小组。
N Engl J Med. 1996 Nov 28;335(22):1621-9. doi: 10.1056/NEJM199611283352201.
9
A United States national reference for fetal growth.美国胎儿生长发育的国家参考标准。
Obstet Gynecol. 1996 Feb;87(2):163-8. doi: 10.1016/0029-7844(95)00386-X.