Karo-Atar Danielle, Gregorieff Alex, King Irah L
Department of Microbiology and Immunology, Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada; McGill Interdisciplinary Initiative in Infection and Immunity, Montreal, Quebec, Canada; McGill Regenerative Medicine Network, Montreal, Quebec, Canada.
McGill Regenerative Medicine Network, Montreal, Quebec, Canada; Department of Pathology, McGill University and Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Trends Parasitol. 2023 Jun;39(6):414-422. doi: 10.1016/j.pt.2023.03.012. Epub 2023 Apr 17.
Intestinal helminths remain highly pervasive throughout the animal kingdom by modulating multiple aspects of the host immune response. The intestinal epithelium functions as a physical barrier as well as a sentinel innate immune tissue with the ability to sense and respond to infectious agents. Although helminths form intimate interactions with the epithelium, comprehensive knowledge about host-helminth interactions at this dynamic interface is lacking. In addition, little is known about the ability of helminths to directly shape the fate of this barrier tissue. Here, we review the diverse pathways by which helminths regulate the epithelium and highlight the emerging field of direct helminth regulation of intestinal stem cell (ISC) fate and function.
肠道蠕虫通过调节宿主免疫反应的多个方面，在整个动物界仍然高度普遍。肠道上皮不仅作为物理屏障发挥作用，还是一种能够感知和应对感染因子的先天性免疫哨兵组织。尽管蠕虫与上皮细胞形成密切的相互作用，但在这个动态界面上，关于宿主-蠕虫相互作用的全面知识仍然缺乏。此外，对于蠕虫直接塑造这种屏障组织命运的能力知之甚少。在这里，我们回顾了蠕虫调节上皮细胞的多种途径，并强调了蠕虫直接调节肠道干细胞（ISC）命运和功能这一新兴领域。
