Department of Immunology and Pathology, Central Clinical School, Monash University, The Alfred Centre, Melbourne, Victoria, Australia.
Department of Immunology and Pathology, Central Clinical School, Monash University, The Alfred Centre, Melbourne, Victoria, Australia.
Trends Parasitol. 2020 Sep;36(9):761-772. doi: 10.1016/j.pt.2020.07.002. Epub 2020 Jul 23.
Gastrointestinal helminth infection still constitutes a major public health issue, particularly in the developing world. As these parasites can undergo a large part of their lifecycle within the intestinal tract the host has developed various structural and cellular specializations at the epithelial barrier to contend with infection. Detailed characterization of these cells will provide important insights about their contributions to the protective responses mediated against helminths. Here, we discuss how key components of the intestinal epithelium may function to limit the initial establishment of helminths, and how these cells are altered during an active response to infection.
肠道寄生虫感染仍然是一个主要的公共卫生问题，特别是在发展中国家。由于这些寄生虫的大部分生命周期都在肠道内进行，宿主在肠道上皮屏障中已经发展出各种结构和细胞特化来应对感染。对这些细胞的详细特征描述将为了解它们对抗寄生虫的保护反应的贡献提供重要的见解。在这里，我们讨论了肠道上皮的关键成分如何发挥作用来限制寄生虫的最初定植，以及这些细胞在对感染的主动反应中是如何改变的。
