Shanghai Institute of Cardiovascular Diseases, Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Alzheimer's Center at Temple, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Trends Endocrinol Metab. 2023 Jun;34(6):373-387. doi: 10.1016/j.tem.2023.03.005. Epub 2023 Apr 17.
Aging triggers a wide range of cellular and molecular aberrations in the body, giving rise to inflammation and associated diseases. In particular, aging is associated with persistent low-grade inflammation even in absence of inflammatory stimuli, a phenomenon commonly referred to as 'inflammaging'. Accumulating evidence has revealed that inflammaging in vascular and cardiac tissues is associated with the emergence of pathological states such as atherosclerosis and hypertension. In this review we survey molecular and pathological mechanisms of inflammaging in vascular and cardiac aging to identify potential targets, natural therapeutic compounds, and other strategies to suppress inflammaging in the heart and vasculature, as well as in associated diseases such as atherosclerosis and hypertension.
衰老是机体触发广泛的细胞和分子失常的原因，导致炎症和相关疾病的发生。特别是，即使没有炎症刺激，衰老也与持续的低度炎症有关，这种现象通常被称为“炎症衰老”。越来越多的证据表明，血管和心脏组织中的炎症衰老与动脉粥样硬化和高血压等病理状态的出现有关。在这篇综述中，我们调查了血管和心脏衰老中炎症衰老的分子和病理机制，以确定潜在的靶点、天然治疗化合物和其他抑制心脏和血管以及相关疾病（如动脉粥样硬化和高血压）中炎症衰老的策略。
