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癌症患者免疫检查点抑制剂治疗中的血压监测。

Blood pressure surveillance in cancer patients treated with immune checkpoint inhibitors.

机构信息

Victorian Heart Institute, Monash University, Melbourne, VIC, Australia.

Monash Heart, Monash Health, Melbourne, VIC, Australia.

出版信息

J Hum Hypertens. 2023 Nov;37(11):1043-1046. doi: 10.1038/s41371-023-00831-z. Epub 2023 Apr 19.

DOI:10.1038/s41371-023-00831-z
PMID:37076569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10632129/
Abstract

Immune checkpoint inhibitors (ICI) are cancer therapies that have been associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). Blood pressure (BP) measurements are routinely performed during day oncology center visits for administration of ICI therapy but are often not assessed temporally to screen and monitor hypertension, which could independently increase the risk of ASCVD in cancer survivorship. This study reports the feasibility of using serial BP measurements from routine visits to day oncology center to diagnose and monitor hypertension control in cancer patients receiving ICIs.

摘要

免疫检查点抑制剂(ICI)是一种癌症治疗药物,与动脉粥样硬化性心血管疾病(ASCVD)风险增加有关。在进行 ICI 治疗的日间肿瘤中心就诊期间,通常会常规测量血压(BP),但通常不会进行时间评估以筛查和监测高血压,而高血压可能会独立增加癌症幸存者 ASCVD 的风险。本研究报告了使用来自日间肿瘤中心常规就诊的连续 BP 测量值来诊断和监测接受 ICI 的癌症患者的高血压控制情况的可行性。

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Blood pressure surveillance in cancer patients treated with immune checkpoint inhibitors.癌症患者免疫检查点抑制剂治疗中的血压监测。
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2
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Immune checkpoint inhibitors in cancer: the increased risk of atherosclerotic cardiovascular disease events and progression of coronary artery calcium.癌症免疫检查点抑制剂:动脉粥样硬化性心血管疾病事件风险增加和冠状动脉钙进展。
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Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque.免疫检查点抑制剂与心血管事件及动脉粥样硬化斑块的关系。
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Cancer patients receiving immune checkpoint inhibitor therapy are at an increased risk for atherosclerotic cardiovascular disease.接受免疫检查点抑制剂治疗的癌症患者发生动脉粥样硬化性心血管疾病的风险增加。
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Case Report: Lung cancer with rare cardiac and other multiple metastases.病例报告:伴有罕见心脏及其他多处转移的肺癌。
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本文引用的文献

1
Immune Checkpoint Inhibitor Therapy in Oncology: Current Uses and Future Directions: State-of-the-Art Review.肿瘤学中的免疫检查点抑制剂疗法:当前应用与未来方向:最新综述
JACC CardioOncol. 2022 Dec 20;4(5):579-597. doi: 10.1016/j.jaccao.2022.09.004. eCollection 2022 Dec.
2
Immune Checkpoint Inhibitors Do Not Increase Short-Term Risk of Hypertension in Cancer Patients: a Systematic Literature Review and Meta-Analysis.免疫检查点抑制剂不会增加癌症患者短期高血压风险:系统文献回顾和荟萃分析。
Hypertension. 2022 Nov;79(11):2611-2621. doi: 10.1161/HYPERTENSIONAHA.122.19865. Epub 2022 Sep 12.
3
2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS).2022年欧洲心脏病学会(ESC)与欧洲血液学协会(EHA)、欧洲治疗放射学与肿瘤学协会(ESTRO)以及国际心脏肿瘤学会(IC-OS)合作制定的心脏肿瘤学指南。
Eur Heart J. 2022 Nov 1;43(41):4229-4361. doi: 10.1093/eurheartj/ehac244.
4
Cardiometabolic Comorbidities in Cancer Survivors: State-of-the-Art Review.癌症幸存者的心脏代谢合并症:最新综述
JACC CardioOncol. 2022 Jun 21;4(2):149-165. doi: 10.1016/j.jaccao.2022.03.005. eCollection 2022 Jun.
5
Immune Checkpoint Therapies and Atherosclerosis: Mechanisms and Clinical Implications: JACC State-of-the-Art Review.免疫检查点治疗与动脉粥样硬化:机制与临床意义:美国心脏病学会临床精要综述。
J Am Coll Cardiol. 2022 Feb 15;79(6):577-593. doi: 10.1016/j.jacc.2021.11.048.
6
Cardiovascular immunotoxicities associated with immune checkpoint inhibitors: a safety meta-analysis.免疫检查点抑制剂相关的心血管免疫毒性:安全性荟萃分析。
Eur Heart J. 2021 Dec 21;42(48):4964-4977. doi: 10.1093/eurheartj/ehab618.
7
Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque.免疫检查点抑制剂与心血管事件及动脉粥样硬化斑块的关系。
Circulation. 2020 Dec 15;142(24):2299-2311. doi: 10.1161/CIRCULATIONAHA.120.049981. Epub 2020 Oct 2.
8
2018 ESC/ESH Guidelines for the management of arterial hypertension.2018年欧洲心脏病学会/欧洲高血压学会动脉高血压管理指南。
Eur Heart J. 2018 Sep 1;39(33):3021-3104. doi: 10.1093/eurheartj/ehy339.
9
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Circulation. 2016 Mar 15;133(11):1104-14. doi: 10.1161/CIRCULATIONAHA.115.020406.
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Heart disease and stroke statistics--2015 update: a report from the American Heart Association.《2015年心脏病和中风统计数据更新:美国心脏协会报告》
Circulation. 2015 Jan 27;131(4):e29-322. doi: 10.1161/CIR.0000000000000152. Epub 2014 Dec 17.