免疫检查点治疗与动脉粥样硬化：机制与临床意义：美国心脏病学会临床精要综述。
Immune Checkpoint Therapies and Atherosclerosis: Mechanisms and Clinical Implications: JACC State-of-the-Art Review.
机构信息
Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA.
Division of Cardiology, Department of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA.
出版信息
J Am Coll Cardiol. 2022 Feb 15;79(6):577-593. doi: 10.1016/j.jacc.2021.11.048.
Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced malignancies in recent years. Numerous reports have detailed the myriad of possible adverse inflammatory effects of immune checkpoint therapies, including within the cardiovascular system. However, these reports have been largely limited to myocarditis. The critical role of inflammation and adaptive immunity in atherosclerosis has been well characterized in preclinical studies, and several emerging clinical studies indicate a potential role of immune checkpoint targeting therapies in the development and exacerbation of atherosclerosis. In this review, we provide an overview of the role of T-cell immunity in atherogenesis and describe the molecular effects and clinical associations of both approved and investigational immune checkpoint therapy on atherosclerosis. We also highlight the role of cholesterol metabolism in oncogenesis and discuss the implications of these associations on future treatment and monitoring of atherosclerotic cardiovascular disease in the oncologic population receiving immune checkpoint therapy.
近年来，免疫检查点抑制剂疗法彻底改变了晚期恶性肿瘤的治疗方式。大量报告详细描述了免疫检查点疗法可能引起的多种炎症不良反应，包括心血管系统。然而，这些报告主要局限于心肌炎。在临床前研究中，炎症和适应性免疫在动脉粥样硬化中的关键作用已得到充分描述，一些新出现的临床研究表明，免疫检查点靶向治疗可能在动脉粥样硬化的发生和恶化中发挥作用。在这篇综述中，我们概述了 T 细胞免疫在动脉粥样硬化形成中的作用，并描述了已批准和正在研究的免疫检查点治疗药物对动脉粥样硬化的分子作用和临床关联。我们还强调了胆固醇代谢在肿瘤发生中的作用，并讨论了这些关联对接受免疫检查点治疗的肿瘤患者发生动脉粥样硬化性心血管疾病的治疗和监测的影响。
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