Department of Gynaecology Endocrine and Reproductive Centre, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Sci Rep. 2023 Apr 19;13(1):6402. doi: 10.1038/s41598-023-33573-6.
The ability of sibling embryos to form blastocysts may reflect the developmental potential of the embryos that were transferred into the uterus. The purpose of the study was to investigate whether the development speed of sibling embryos positively reflects the live birth rate following fresh embryo transfer. We examined 1262 cycles of women who underwent day 3 (D3) cleavage embryo transfer in the Peking Union Medical College Hospital in 2015-2020, who were divided into three groups (D5, D5 + D6, and D6) according to blastocyst formation. The live birth rate in patients with blastocysts that formed on D6 was significantly lower than the other two groups (36.1%, 45.6% and 44.7%, P < 0.05). For women with blastocysts that formed on D6, the live birth rate was higher in those with more good quality blastocysts than poor-quality blastocysts (42.4 vs 32.3%, P < 0.05). Multiple regression analysis showed that the blastocyst development speed of sibling embryos was an independent factor affecting live birth after fresh embryo transfer (P < 0.05). We concluded that the blastocyst development speed of sibling embryos may reflect live birth rate following the transfer of D3 cleavage embryos.
胚胎能否形成囊胚可能反映了被移植到子宫内胚胎的发育潜能。本研究旨在探讨第三天（D3）卵裂胚胎移植后胚胎发育速度是否能正向反映新鲜胚胎移植后的活产率。我们分析了 2015 年至 2020 年在我院行 D3 卵裂期胚胎移植的 1262 个周期的患者，根据囊胚形成情况将患者分为三组（D5、D5+D6、D6）。D6 日形成囊胚的患者活产率明显低于其他两组（36.1%、45.6%和 44.7%，P<0.05）。对于 D6 日形成囊胚的患者，优质囊胚患者的活产率高于非优质囊胚患者（42.4% vs 32.3%，P<0.05）。多因素回归分析显示，胚胎发育速度是影响新鲜胚胎移植后活产率的独立因素（P<0.05）。我们得出结论，胚胎发育速度可能反映了第三天卵裂胚胎移植后的活产率。
