Department of Pathology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India.
Department of Obstetrics and Gynaecology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India.
Indian J Pathol Microbiol. 2023 Apr-Jun;66(2):301-306. doi: 10.4103/ijpm.ijpm_237_21.
Coronavirus 2019 infection (COVID 19) is an ongoing pandemic caused by pathogenic RNA viruses called severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). It has affected people of all ages, with high morbidity and mortality among the elderly and immunocompromised population. Limited information is available on the effects of COVID-19 infection on pregnancy.
To describe the histopathological changes in the placental tissue of SARS-CoV-2 infected term mothers with no comorbidities and to correlate with neonatal outcome.
This observational study was conducted in the Department of Pathology, KMCH institute of health sciences and research, Coimbatore from May 1, 2020 to November 30, 2020 for 6 months. Placental tissues of all COVID-19-positive term mothers with no comorbidities were included in this study. Histopathological examination of placentae was carried out and clinical data of mothers and newborn babies were obtained from medical records.
Histopathological examination of 64 placental tissue of COVID-19 mothers showed predominantly the features of fetal vascular malperfusion like stem villi vasculature thrombus, villous congestion, and avascular villi. No significant correlation was obtained in comparison with parity and symptomatic status of the mothers. However, histopathological changes were more prominent among symptomatic patients. The newborn babies born to these mothers showed no adverse outcome.
This study concluded that though COVID-19 infection in normal term pregnant women was associated with increased prevalence of features of fetal vascular malperfusion, there was no significant morbidity in the health status of both COVID-19 mothers and their neonates.
2019 年冠状病毒感染（COVID-19）是一种由称为严重急性呼吸系统综合征冠状病毒 2 型（SARS-CoV-2）的致病性 RNA 病毒引起的正在进行的大流行。它影响了各个年龄段的人，老年人和免疫功能低下人群的发病率和死亡率较高。关于 COVID-19 感染对妊娠的影响，信息有限。
描述无合并症的 SARS-CoV-2 感染足月母亲的胎盘组织的组织病理学变化，并与新生儿结局相关联。
这项观察性研究于 2020 年 5 月 1 日至 11 月 30 日在钦奈的 KMCH 健康科学与研究学院病理学系进行，为期 6 个月。本研究纳入了所有无合并症的 COVID-19 阳性足月母亲的胎盘组织。对胎盘进行组织病理学检查，并从病历中获取母亲和新生儿的临床数据。
对 64 例 COVID-19 母亲的胎盘组织进行组织病理学检查，主要表现为胎儿血管灌注不良的特征，如胎绒毛血管血栓、绒毛充血和无血管绒毛。与母亲的产次和症状状态相比，未获得显著相关性。然而，在有症状的患者中，组织病理学变化更为明显。这些母亲所生的新生儿没有不良结局。
本研究表明，尽管 COVID-19 在正常足月孕妇中的感染与胎儿血管灌注不良特征的患病率增加有关，但 COVID-19 母亲及其新生儿的健康状况均无明显发病率。
