Chen Mao, Guo Peiwen, Ru Xufang, Chen Yujie, Zuo Shilun, Feng Hua
Department of Neurology, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.
Front Pharmacol. 2023 Apr 3;14:1145605. doi: 10.3389/fphar.2023.1145605. eCollection 2023.
Subarachnoid hemorrhage (SAH) can lead to damage to the myelin sheath in white matter. Through classification and analysis of relevant research results, the discussion in this paper provides a deeper understanding of the spatiotemporal change characteristics, pathophysiological mechanisms and treatment strategies of myelin sheath injury after SAH. The research progress for this condition was also systematically reviewed and compared related to myelin sheath in other fields. Serious deficiencies were identified in the research on myelin sheath injury and treatment after SAH. It is necessary to focus on the overall situation and actively explore different treatment methods based on the spatiotemporal changes in the characteristics of the myelin sheath, as well as the initiation, intersection and common action point of the pathophysiological mechanism, to finally achieve accurate treatment. We hope that this article can help researchers in this field to further clarify the challenges and opportunities in the current research on myelin sheath injury and treatment after SAH.
蛛网膜下腔出血(SAH)可导致白质中髓鞘损伤。通过对相关研究结果的分类和分析,本文的讨论有助于更深入地了解SAH后髓鞘损伤的时空变化特征、病理生理机制及治疗策略。还对该病症的研究进展进行了系统综述,并与其他领域的髓鞘研究进行了比较。研究发现SAH后髓鞘损伤及治疗方面存在严重不足。有必要从全局着眼,根据髓鞘特征的时空变化以及病理生理机制的起始、交叉和共同作用点,积极探索不同的治疗方法,最终实现精准治疗。我们希望本文能帮助该领域的研究人员进一步明确当前SAH后髓鞘损伤及治疗研究中的挑战与机遇。