Pateromichelakis S, Rood J P
Br J Anaesth. 1986 Jun;58(6):649-52. doi: 10.1093/bja/58.6.649.
The effects of i.a. administered lignocaine on the in vivo response of the vascular bed supplied by the lingual, external maxillary and posterior auricular branches of the common carotid artery were studied in the rat. Infusions of lignocaine in concentrations of 10-1000 micrograms ml-1 administered at the rate of 0.05 ml min-1 for 10 min did not affect vascular resistance or arterial pressure in the common carotid artery. However, following such infusions, the increase of vascular resistance caused by bolus doses of adrenaline (20-120 ng in 0.1 ml) was inhibited, indicating lignocaine-adrenaline antagonism. Responses to adrenaline remained significantly depressed 60 min after the termination of a 100-micrograms ml-1 or higher lignocaine infusion.
在大鼠中研究了经动脉内给药的利多卡因对由颈总动脉的舌、上颌外和耳后分支供应的血管床的体内反应的影响。以0.05 ml min-1的速率输注浓度为10 - 1000微克 ml-1的利多卡因10分钟，并未影响颈总动脉的血管阻力或动脉血压。然而，在进行此类输注后，由大剂量肾上腺素（0.1 ml中含20 - 120 ng）引起的血管阻力增加受到抑制，表明存在利多卡因 - 肾上腺素拮抗作用。在100微克 ml-1或更高浓度的利多卡因输注终止60分钟后，对肾上腺素的反应仍显著受到抑制。
