市售局部麻醉溶液对离体兔耳动脉的影响。

The effects of commercial local anaesthetic solutions on the isolated rabbit ear artery.

作者信息

Gerke D C, Frewin D B, Waterson J G

出版信息

Aust Dent J. 1977 Aug;22(4):289-94. doi: 10.1111/j.1834-7819.1977.tb04514.x.

DOI:10.1111/j.1834-7819.1977.tb04514.x

Abstract

The response of an isolated artery preparation to commercial local anaesthetic solutions containing either prilocaine or lignocaine in the presence of adrenaline or noradrenaline has been examined. In low doses, both local anaesthetics were found to augment the constrictor response to adrenaline, wheras at higher doses the effect of adrenaline was significantly depressed by them. In contrast, noradrenaline's vasoconstrictor response was not potentiated by low doses of lignocaine, although higher dose levels caused a significant reduction in its vasoconstrictor effect.

摘要

已对离体动脉制剂在肾上腺素或去甲肾上腺素存在的情况下对含有丙胺卡因或利多卡因的市售局部麻醉溶液的反应进行了研究。在低剂量时，发现两种局部麻醉药都会增强对肾上腺素的收缩反应，而在高剂量时，它们会显著抑制肾上腺素的作用。相比之下，低剂量的利多卡因不会增强去甲肾上腺素的血管收缩反应，尽管高剂量会使其血管收缩作用显著降低。