单剂量和多剂量缓释Oros氧烯洛尔给药系统在年轻血压正常者和老年高血压患者中药代动力学特征的比较。
Comparison of pharmacokinetic profiles of single and multiple doses of a slow release Oros oxprenolol delivery system in young normotensive and elderly hypertensive subjects.
作者信息
Bradbrook I D, Babiker M, Crome P, Gillies H C, Morrison P J, Rogers H J, Shotton P
出版信息
Br J Clin Pharmacol. 1986 Apr;21(4):371-6. doi: 10.1111/j.1365-2125.1986.tb05209.x.
Abstract
Oxprenolol in an Oros 8/130 sustained release osmotic pump system (equivalent to 120 mg oxprenolol hydrochloride in a conventional formulation and releasing 8 mg h-1) was given to eight normal young subjects (mean age 23 years) and eight elderly hypertensive patients (mean age 77 years). The plasma concentration-time profiles of oxprenolol were determined over 32 h using gas liquid chromatography after the initial dose and following seven doses. The elderly patients had a significantly higher AUC and maximum plasma oxprenolol concentration following both the first and final doses studied. It is unlikely that this difference is due to a prolonged absorption phase in the elderly patients. Reduced drug clearance seems the most probable explanation.
摘要
将氧烯洛尔装入渗透型8/130缓释渗透泵系统（相当于常规制剂中的120毫克盐酸氧烯洛尔，释放速率为8毫克/小时），给予8名正常年轻受试者（平均年龄23岁）和8名老年高血压患者（平均年龄77岁）。在首次给药后以及七次给药后，采用气相色谱法在32小时内测定氧烯洛尔的血浆浓度-时间曲线。在研究的首次和末次给药后，老年患者的曲线下面积（AUC）和血浆氧烯洛尔最大浓度均显著更高。这种差异不太可能是由于老年患者吸收期延长所致。药物清除率降低似乎是最可能的解释。
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