Bradbrook I D, Babiker M, Crome P, Gillies H C, Morrison P J, Rogers H J, Shotton P
Br J Clin Pharmacol. 1986 Apr;21(4):371-6. doi: 10.1111/j.1365-2125.1986.tb05209.x.
Oxprenolol in an Oros 8/130 sustained release osmotic pump system (equivalent to 120 mg oxprenolol hydrochloride in a conventional formulation and releasing 8 mg h-1) was given to eight normal young subjects (mean age 23 years) and eight elderly hypertensive patients (mean age 77 years). The plasma concentration-time profiles of oxprenolol were determined over 32 h using gas liquid chromatography after the initial dose and following seven doses. The elderly patients had a significantly higher AUC and maximum plasma oxprenolol concentration following both the first and final doses studied. It is unlikely that this difference is due to a prolonged absorption phase in the elderly patients. Reduced drug clearance seems the most probable explanation.
将氧烯洛尔装入渗透型8/130缓释渗透泵系统（相当于常规制剂中的120毫克盐酸氧烯洛尔，释放速率为8毫克/小时），给予8名正常年轻受试者（平均年龄23岁）和8名老年高血压患者（平均年龄77岁）。在首次给药后以及七次给药后，采用气相色谱法在32小时内测定氧烯洛尔的血浆浓度-时间曲线。在研究的首次和末次给药后，老年患者的曲线下面积（AUC）和血浆氧烯洛尔最大浓度均显著更高。这种差异不太可能是由于老年患者吸收期延长所致。药物清除率降低似乎是最可能的解释。
