Hurwitz N
Br Med J. 1969 Mar 1;1(5643):536-9. doi: 10.1136/bmj.1.5643.536.
Predisposing factors were sought in 118 patients who developed adverse drug reactions in hospital. Significantly more patients of 60 years and over, and more women than men, developed adverse drug reactions. Patients with reactions had more drugs before the development of the reaction than patients who did not develop reactions. A previous adverse drug reaction and a history of allergic disease were significant factors, while a history of jaundice or the presence of diabetes mellitus and renal disease was not.
对118例在医院发生药物不良反应的患者进行了易感因素调查。60岁及以上的患者发生药物不良反应的比例明显更高，女性比男性更多。发生不良反应的患者在出现反应前使用的药物比未发生反应的患者更多。既往药物不良反应和过敏疾病史是重要因素，而黄疸病史、糖尿病或肾病则不是。
