Université Lyon, Université Claude Bernard Lyon 1, Institut de Recherches sur la Catalyse et l'Environnement de Lyon (IRCELYON), UMR CNRS 5256, Villeurbanne, France.
Nantes Université, CNRS, Institut des Matériaux de Nantes Jean Rouxel, IMN, Nantes F-44000, France.
J Mater Chem B. 2023 May 10;11(18):3979-3984. doi: 10.1039/d3tb00537b.
Silver nanoparticles are known and widely used for their antimicrobial activities. Nevertheless, once they are released into the natural or biological environments, they can become toxic with time, because of the dissolution of some Ag(I) ions that can then react with thiol-based molecules, such as glutathione and/or compete with copper proteins. These assumptions are based on the high affinity of the soft acid Ag(I) and the soft base thiolates and the exchange reactions that are involved in complex physiological media. Here we synthesized and fully characterized two new 2D silver thiolate coordination polymers (CPs) that exhibit a reversible 2D-to-1D structural transformation in the presence of an excess of thiol molecules. This dimensionality change induces also a switch of the yellow emission of the Ag-thiolate CP. This study highlights that these highly stable silver-thiolate CPs, in basic, acidic and oxidant media can undergo a complete dissolution-recrystallization mechanism upon thiol exchange reactions.
银纳米粒子因其抗菌活性而被广泛认知和应用。然而，一旦它们被释放到自然或生物环境中，随着时间的推移，由于一些 Ag(I) 离子的溶解，它们可能会变得有毒，这些 Ag(I) 离子可以与含巯基的分子（如谷胱甘肽和/或与铜蛋白竞争）发生反应。这些假设是基于软酸 Ag(I) 和软巯基的高亲和力，以及涉及复杂生理介质的交换反应。在这里，我们合成并充分表征了两种新的二维银硫醇配位聚合物 (CPs)，它们在过量硫醇分子的存在下表现出二维到一维的结构转变的可逆性。这种维度变化也诱导了 Ag-硫醇 CP 的黄色发射的开关。这项研究强调，这些高度稳定的银硫醇 CP，在碱性、酸性和氧化剂介质中，可以在巯基交换反应下经历完全的溶解-再结晶机制。
