Pathology Unit, Department of Medical Sciences, University of Turin, Via Santena 7, 10126, Turin, Italy.
Pathology Unit, Città della Salute e della Scienza of Turin, Turin, Italy.
Virchows Arch. 2023 Aug;483(2):245-250. doi: 10.1007/s00428-023-03542-5. Epub 2023 Apr 20.
Solitary fibrous tumor is a mesenchymal tumor of intermediate malignant potential characterized by a recurrent NAB2::STAT6 fusion and STAT6 nuclear expression. Primary thyroid solitary fibrous tumor is relatively uncommon, with 45 cases described in the English literature to date. Although its histologic features are characteristic, its diagnosis in the thyroid can be problematic, especially in small biopsies or cytology specimens. We herein present three new cases of thyroid solitary fibrous tumor, one of which is malignant, with new insights on the morphological spectrum and malignant potential of this tumor. We additionally provide a review of the literature with a focus on the clues and challenges of a preoperative cytological diagnosis of this tumor, which can nowadays be supported by STAT6 nuclear expression, when appropriately suspected.
孤立性纤维瘤是一种间叶性肿瘤，具有中等恶性潜能，其特征是反复出现的 NAB2::STAT6 融合和 STAT6 核表达。原发性甲状腺孤立性纤维瘤相对少见，迄今为止，英文文献中已有 45 例报道。尽管其组织学特征具有特征性，但在甲状腺中的诊断可能存在问题，尤其是在小活检或细胞学标本中。本文介绍了 3 例新的甲状腺孤立性纤维瘤病例，其中 1 例为恶性，对该肿瘤的形态谱和恶性潜能有了新的认识。此外，我们还对文献进行了回顾，重点介绍了术前细胞学诊断该肿瘤的线索和挑战，如今在适当怀疑时，可通过 STAT6 核表达来支持诊断。
