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Remimazolam: a new string to the TIVA bow.

作者信息

Hirota Kazuyoshi

机构信息

Department of Anesthesiology, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan.

出版信息

J Anesth. 2023 Jun;37(3):335-339. doi: 10.1007/s00540-023-03186-4. Epub 2023 Apr 20.

DOI:10.1007/s00540-023-03186-4
PMID:37079100
Abstract
摘要

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Remimazolam: a new string to the TIVA bow.瑞米唑仑：全凭静脉麻醉的新利器。
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2
A miniature pig model of pharmacological tolerance to long-term sedation with the intravenous benzodiazepines; midazolam and remimazolam.一种静脉使用苯二氮䓬类药物（咪达唑仑和瑞马唑仑）引起长期镇静性药物耐受的小型猪模型。
Eur J Pharmacol. 2021 Apr 5;896:173886. doi: 10.1016/j.ejphar.2021.173886. Epub 2021 Jan 23.
3
A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part I. Safety, efficacy, and basic pharmacokinetics.一项安慰剂和咪达唑仑对照的 I 期单递增剂量研究，评估 remimazolam（CNS 7056）的安全性、药代动力学和药效学：第 I 部分。安全性、疗效和基本药代动力学。
Anesth Analg. 2012 Aug;115(2):274-83. doi: 10.1213/ANE.0b013e31823f0c28. Epub 2011 Dec 20.
4
A placebo- and midazolam-controlled phase I single ascending-dose study evaluating the safety, pharmacokinetics, and pharmacodynamics of remimazolam (CNS 7056): Part II. Population pharmacokinetic and pharmacodynamic modeling and simulation.一项安慰剂和咪达唑仑对照的 I 期单递增剂量研究，评估雷米唑仑（CNS 7056）的安全性、药代动力学和药效学：第二部分。群体药代动力学和药效学建模与模拟。
Anesth Analg. 2012 Aug;115(2):284-96. doi: 10.1213/ANE.0b013e318241f68a. Epub 2012 Jan 16.
5
Economic benefits of remimazolam compared to midazolam and propofol for procedural sedation in colonoscopies and bronchoscopies.雷米唑仑与咪达唑仑和丙泊酚在结肠镜检查和支气管镜检查中用于镇静的经济学效益比较。
Curr Med Res Opin. 2023 May;39(5):691-699. doi: 10.1080/03007995.2023.2196198. Epub 2023 Apr 11.
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Remimazolam: a new reminder to keep our guard up.瑞米唑仑：敲响警钟，让我们保持警惕。
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Impact of concurrent remifentanil on the sedative effects of remimazolam, midazolam and propofol in cynomolgus monkeys.氯雷他定对猕猴咪达唑仑、依托咪酯和丙泊酚镇静效果的影响。
Eur J Pharmacol. 2021 Jan 5;890:173639. doi: 10.1016/j.ejphar.2020.173639. Epub 2020 Oct 14.
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A phase III study evaluating the efficacy and safety of remimazolam (CNS 7056) compared with placebo and midazolam in patients undergoing colonoscopy.一项评估雷米佐仑（CNS 7056）与安慰剂和咪达唑仑在接受结肠镜检查患者中的疗效和安全性的 III 期研究。
Gastrointest Endosc. 2018 Sep;88(3):427-437.e6. doi: 10.1016/j.gie.2018.04.2351. Epub 2018 Apr 30.
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Awaiting remimazolam guidance.等待瑞马唑仑的指导。
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Remimazolam should be antagonized by an adequate flumazenil.瑞马唑仑应用适当剂量的氟马西尼拮抗。
J Anesth. 2023 Feb;37(1):164-165. doi: 10.1007/s00540-022-03117-9. Epub 2022 Oct 5.

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Remimazolam-based total intravenous anesthesia in a patient with a confirmed diagnosis of malignant hyperthermia: a case report.确诊恶性高热患者基于瑞米唑仑的全静脉麻醉：一例报告
JA Clin Rep. 2024 Apr 22;10(1):26. doi: 10.1186/s40981-024-00710-7.
2
Successful reversal of remimazolam anesthesia in a "cannot intubate, can ventilate" situation: a case report.“无法插管，能通气”情况下瑞米唑仑麻醉的成功逆转：一例报告
JA Clin Rep. 2023 Jul 24;9(1):46. doi: 10.1186/s40981-023-00638-4.

本文引用的文献

1
Long-term delayed emergence after remimazolam-based general anesthesia: a case report.基于瑞马唑仑的全身麻醉后长期延迟苏醒：一例病例报告。
JA Clin Rep. 2022 Oct 19;8(1):86. doi: 10.1186/s40981-022-00576-7.
2
Association between remimazolam and postoperative delirium in older adults undergoing elective cardiovascular surgery: a prospective cohort study.瑞马唑仑与择期心血管手术老年患者术后谵妄的关联：一项前瞻性队列研究。
J Anesth. 2023 Feb;37(1):13-22. doi: 10.1007/s00540-022-03119-7. Epub 2022 Oct 12.
3
Profile of Remimazolam in Anesthesiology: A Narrative Review of Clinical Research Progress.
雷米唑仑在麻醉学中的应用：临床研究进展的叙述性综述。
Drug Des Devel Ther. 2022 Oct 3;16:3431-3444. doi: 10.2147/DDDT.S375957. eCollection 2022.
4
Caution!! Reappearance of remimazolam effect after a flumazenil bolus: a larger bolus of flumazenil and a lower total remimazolam clearance are higher risks.注意！！氟马西尼推注后瑞米唑仑效应再现：更大剂量的氟马西尼推注和更低的瑞米唑仑总清除率风险更高。
J Anesth. 2023 Feb;37(1):1-5. doi: 10.1007/s00540-022-03107-x. Epub 2022 Sep 16.
5
Anaphylaxis following remimazolam administration during induction of anaesthesia.麻醉诱导期间使用瑞米唑仑后发生过敏反应。
Br J Anaesth. 2022 Nov;129(5):e122-e124. doi: 10.1016/j.bja.2022.07.047. Epub 2022 Aug 30.
6
Quality of recovery in patients administered remimazolam versus those administered an inhalant agent for the maintenance of general anesthesia: a randomized control trial.接受雷米唑仑给药与接受吸入性麻醉维持药物给药的患者的恢复质量：一项随机对照试验。
BMC Anesthesiol. 2022 Jul 16;22(1):226. doi: 10.1186/s12871-022-01770-x.
7
Remimazolam induced cognitive dysfunction in mice via glutamate excitotoxicity.瑞米唑仑通过谷氨酸兴奋性毒性诱导小鼠认知功能障碍。
Transl Neurosci. 2022 May 31;13(1):104-115. doi: 10.1515/tnsci-2022-0220. eCollection 2022 Jan 1.
8
Effects of Remimazolam vs. Sevoflurane Anesthesia on Intraoperative Hemodynamics in Patients with Gastric Cancer Undergoing Robotic Gastrectomy: A Propensity Score-Matched Analysis.瑞米唑仑与七氟醚麻醉对机器人胃癌根治术患者术中血流动力学的影响：一项倾向评分匹配分析
J Clin Med. 2022 May 8;11(9):2643. doi: 10.3390/jcm11092643.
9
Efficacy of remimazolam versus midazolam for procedural sedation: post hoc integrated analyses of three phase 3 clinical trials.瑞米唑仑与咪达唑仑用于诊疗镇静的疗效：三项3期临床试验的事后综合分析
Endosc Int Open. 2022 Apr 14;10(4):E378-E385. doi: 10.1055/a-1743-1936. eCollection 2022 Apr.
10
Protective Effects of Remimazolam on Cerebral Ischemia/Reperfusion Injury in Rats by Inhibiting of NLRP3 Inflammasome-Dependent Pyroptosis.雷米加佐姆通过抑制 NLRP3 炎性小体依赖性细胞焦亡对大鼠脑缺血/再灌注损伤的保护作用。
Drug Des Devel Ther. 2022 Feb 18;16:413-423. doi: 10.2147/DDDT.S344240. eCollection 2022.