Department of Dermatology, Inselspital University Hospital of Bern, Bern, Switzerland.
Dermatology Department, S. Bortolo Hospital, Vicenza, Italy.
Expert Rev Clin Immunol. 2023 Jul-Dec;19(7):717-744. doi: 10.1080/1744666X.2023.2205640. Epub 2023 Apr 28.
Phototherapy has been one of the first and still frequently used treatment modality for psoriasis. In the last decades, different types of lasers have been used for the treatment of psoriasis and other inflammatory skin diseases with variable success.
Efficacy and safety of laser devices and intense pulsed light for the treatment of psoriasis. The literature search was conducted using the bibliographic databases MEDLINE, EMBASE, and Cochrane. Search terms included 'laser' AND 'psoriasis,' 'IPL' AND 'psoriasis,' 'intense pulsed light' AND 'psoriasis.'
Due to its high efficacy and safety profile, 308-nm Excimer laser retains its specific place in the treatment of plaque psoriasis as a first- or second-line therapy in mild disease or as an adjuvant treatment in case of partial response to systemic treatments in moderate-to-severe disease. Vascular lasers remain a last line therapy that can be tried in patients with recalcitrant limited plaques or nail affection. They are easy to apply and have a very good safety profile and tolerability, but the efficacy is limited. Fractional ablative lasers for application of laser-assisted drug delivery appear interesting and a topic for further research. When using lasers for psoriasis, a good pre-treatment is mandatory.
光疗是治疗银屑病的最初方法之一，目前仍然经常使用。在过去的几十年中，已经使用了不同类型的激光治疗银屑病和其他炎症性皮肤病，取得了不同程度的成功。
激光设备和强脉冲光治疗银屑病的疗效和安全性。文献检索使用了 MEDLINE、EMBASE 和 Cochrane 书目数据库。搜索词包括“激光”和“银屑病”、“IPL”和“银屑病”、“强脉冲光”和“银屑病”。
由于其高效和安全的特性，308nm 准分子激光在治疗斑块型银屑病方面保留了其特定的地位，可作为轻度疾病的一线或二线治疗方法，或在中度至重度疾病对全身治疗有部分反应的情况下作为辅助治疗。血管激光仍然是一种最后的治疗方法，可以尝试用于治疗顽固的局限性斑块或指甲受累。它们易于应用，具有非常好的安全性和耐受性，但疗效有限。用于激光辅助药物输送的剥脱性和非剥脱性点阵激光似乎很有前途，是进一步研究的课题。在使用激光治疗银屑病时，必须进行良好的预处理。
