Taniguchi M, Ishikawa H, Sakagami T
Biochim Biophys Acta. 1986 May 21;876(3):631-8.
Incorporation of [32P]orthophosphate into phosphatidylcholine, lysophosphatidylcholine and molecular species of phosphatidylcholine in vivo was observed in liver, plasma and erythrocytes of bile duct-ligated or sham-operated rats. Both the amount and radioactivity of dienoic species of phosphatidylcholine in all tissues examined increased in bile duct-ligated rats as compared to sham-operated rats. The experiments in vivo and in vitro showed that the ratio of lysophosphatidylcholine to phosphatidylcholine transferred to erythrocytes from plasma in sham-operated rats was much higher than that in bile duct-ligated rats. It is suggested that one of the mechanisms by which abnormal erythrocytes appear might be explained by the facilitated and direct transfer of phosphatidylcholine, which is caused by the interaction of erythrocytes with bile acid in bile duct-ligated rat plasma.
在胆管结扎或假手术大鼠的肝脏、血浆和红细胞中观察到体内[32P]正磷酸盐掺入磷脂酰胆碱、溶血磷脂酰胆碱及磷脂酰胆碱的分子种类。与假手术大鼠相比，胆管结扎大鼠所有检测组织中磷脂酰胆碱二烯酸种类的含量和放射性均增加。体内和体外实验表明，假手术大鼠血浆中溶血磷脂酰胆碱与转移至红细胞的磷脂酰胆碱的比例远高于胆管结扎大鼠。提示胆管结扎大鼠血浆中红细胞与胆汁酸相互作用导致磷脂酰胆碱易化和直接转移，这可能是异常红细胞出现的机制之一。
