甲状腺状态和禁食对大鼠肝脏中辅酶A和丙二酰辅酶A浓度的影响。
Effects of thyroid state and fasting on the concentrations of CoA and malonyl-CoA in rat liver.
作者信息
Lund H, Stakkestad J A, Skrede S
出版信息
Biochim Biophys Acta. 1986 May 21;876(3):685-7. doi: 10.1016/0005-2760(86)90058-5.
Liver CoA is markedly higher in hyperthyroid rats as compared to hypothyroid rats, and in fasted rats as compared to fed rats. In hyperthyroid rats the CoA is increased mainly in the cytosol, while in fasted rats the increase is mainly in the mitochondria. Malonyl-CoA is markedly higher in hypothyroid rats than in euthyroid and hyperthyroid rats. With fasting, malonyl-CoA drops 80-85% in all thyroid states. These findings are discussed in relation to the regulation of fatty acid oxidation in the liver.
与甲状腺功能减退的大鼠相比，甲状腺功能亢进的大鼠肝脏辅酶A（CoA）水平显著更高；与进食的大鼠相比，禁食大鼠的肝脏辅酶A水平也显著更高。在甲状腺功能亢进的大鼠中，辅酶A主要在细胞质中增加，而在禁食大鼠中，增加主要在线粒体中。丙二酰辅酶A在甲状腺功能减退的大鼠中明显高于甲状腺功能正常和甲状腺功能亢进的大鼠。禁食时，在所有甲状腺状态下，丙二酰辅酶A下降80 - 85%。结合肝脏中脂肪酸氧化的调节对这些发现进行了讨论。
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