School of Life Sciences, Tianjin University, Tianjin, 300072, PR China.
Department of Biochemistry and Molecular Biology, School of Basic Medicine, Ningxia Medical University, Yinchuan, Ningxia, 750004, PR China.
Biochimie. 2023 Sep;212:60-75. doi: 10.1016/j.biochi.2023.04.011. Epub 2023 Apr 18.
As a multi-potency cytokine, leptin not only plays a crucial role in controlling weight and energy homeostasis but also participates in the metabolic balance in the human body. Leptin is a small helical protein with a molecular weight of 16 kDa. It can interact with multiple subtypes of its receptors to initiate intracellular signal transduction and exerts physiological effects. Disturbances in leptin signaling may lead to obesity and a variety of metabolic diseases. Leptin was also found to be a critical factor in many diseases of the elderly. In this review, we focus on recent advances in the structural and molecular mechanisms of leptin signaling through its receptors with the aim of a deeper understanding of leptin-related diseases.
作为一种多功能细胞因子，瘦素不仅在控制体重和能量平衡方面起着关键作用，还参与人体的代谢平衡。瘦素是一种分子量为 16 kDa 的小型螺旋蛋白。它可以与多种亚型的受体相互作用，启动细胞内信号转导，并发挥生理作用。瘦素信号的紊乱可能导致肥胖和多种代谢疾病。瘦素也被发现是许多老年疾病的关键因素。在这篇综述中，我们重点介绍了瘦素通过其受体的信号转导的结构和分子机制的最新进展，旨在更深入地了解与瘦素相关的疾病。
