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肿瘤免疫治疗中的免疫原性细胞死亡。

Immunogenic cell death in cancer immunotherapy.

机构信息

Department of Biomedical Science and Engineering, Graduate School, Inha University, Incheon 22212, Korea.

Affiliated Cancer Institute & Hospital and Key Laboratory for Cell Homeostasis and Cancer Research of Guangdong Higher Education Institutes, Guangzhou Medical University, Guangzhou 910095, China.

出版信息

BMB Rep. 2023 May;56(5):275-286. doi: 10.5483/BMBRep.2023-0024.

Abstract

Cancer immunotherapy has been acknowledged as a new paradigm for cancer treatment, with notable therapeutic effects on certain cancer types. Despite their significant potential, clinical studies over the past decade have revealed that cancer immunotherapy has low response rates in the majority of solid tumors. One of the key causes for poor responses is known to be the relatively low immunogenicity of solid tumors. Because most solid tumors are immune desert 'cold tumors' with antitumor immunity blocked from the onset of innate immunity, combination therapies that combine validated T-based therapies with approaches that can increase tumor-immunogenicity are being considered as relevant therapeutic options. This review paper focuses on immunogenic cell death (ICD) as a way of enhancing immunogenicity in tumor tissues. We will thoroughly review how ICDs such as necroptosis, pyroptosis, and ferroptosis can improve anti-tumor immunity and outline clinical trials targeting ICD. Finally, we will discuss the potential of ICD inducers. as an adjuvant for cancer immunotherapy.[BMB Reports 2023; 56(5): 275-286].

摘要

癌症免疫疗法已被公认为癌症治疗的新范例,对某些癌症类型具有显著的治疗效果。尽管具有巨大的潜力,但过去十年的临床研究表明,癌症免疫疗法在大多数实体肿瘤中的反应率较低。导致反应不佳的一个主要原因是实体肿瘤的免疫原性相对较低。由于大多数实体肿瘤是免疫荒漠“冷肿瘤”,其抗肿瘤免疫从先天免疫开始就受到阻断,因此正在考虑将联合疗法,即将已验证的 T 细胞疗法与能够增加肿瘤免疫原性的方法相结合,作为相关的治疗选择。这篇综述文章重点介绍免疫原性细胞死亡(ICD)作为增强肿瘤组织免疫原性的一种方法。我们将详细回顾坏死性细胞凋亡、细胞焦亡和铁死亡等 ICD 如何改善抗肿瘤免疫,并概述针对 ICD 的临床试验。最后,我们将讨论 ICD 诱导剂作为癌症免疫治疗辅助剂的潜力。[BMB 报告 2023;56(5):275-286]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e22/10230015/d986a6a366d7/bmb-56-5-275-f1.jpg

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