Lee Jumi, Yoo Inhwan, Ahn Ihyeon, Lee Namgyu
Department of Biomedical Science & Systems Biology, Dankook University, Cheonan 31116, Korea.
Department of Microbiology and Biotechnology, Dankook University, Cheonan 31116, Korea.
BMB Rep. 2025 Jun;58(6):233-237.
Ferroptosis, an iron-dependent form of programmed cell death, is primarily driven by the accumulation of lipid peroxides through radical generation, notably via the Fenton reaction. Emerging evidence highlights the intricate link between ferroptosis and cellular metabolism, with metabolic enzymes playing pivotal roles in its regulation. Sulfide quinone oxidoreductase (SQOR), traditionally recognized for its role in hydrogen sulfide (H2S) detoxification and electron transport chain (ETC) activation, has recently been identified as a promiscuous enzyme with a novel function in ferroptosis regulation. This review explores SQOR's canonical function in H2S metabolism and its emerging role in ferroptosis resistance through the production of ubiquinol and hydropersulfides, radical-trapping antioxidants. Additionally, we provide insights into potential future research directions, emphasizing SQOR's therapeutic relevance in ferroptosis-associated diseases. [BMB Reports 2025; 58(6): 233-237].
铁死亡是一种铁依赖性的程序性细胞死亡形式，主要由脂质过氧化物通过自由基生成而积累所驱动，特别是通过芬顿反应。新出现的证据凸显了铁死亡与细胞代谢之间的复杂联系，代谢酶在其调控中发挥着关键作用。硫化物醌氧化还原酶（SQOR），传统上因其在硫化氢（H2S）解毒和电子传递链（ETC）激活中的作用而被认可，最近被鉴定为一种具有铁死亡调控新功能的混杂酶。本综述探讨了SQOR在H2S代谢中的经典功能，以及它通过生成泛醇和氢过硫化物（自由基捕获抗氧化剂）在抗铁死亡方面的新作用。此外，我们还对未来潜在的研究方向提供了见解，强调了SQOR在铁死亡相关疾病中的治疗相关性。[《BMB报告》2025年；58(6): 233 - 237]
