Fairshter R D
Bull Eur Physiopathol Respir. 1986 Mar-Apr;22(2):119-25.
Normal control subjects and individuals with chronic obstructive pulmonary disease (COPD) were studied by measuring routine lung function tests as well as maximal (MEFV) and partial expiratory flow-volume (PEFV) curves and lung elastic recoil (Pst,L) before and after a total lung capacity (TLC) volume history. In the normal subjects: before bronchodilators airflow increased significantly, whereas Pst,L and upstream segment resistance (Rus) decreased significantly following inspiration to TLC; after administration of inhaled bronchodilators, flow rates were higher on the PEFV than on MEFV curves; nevertheless, because Pst,L decreased substantially following a deep breath, post-bronchodilator Rus was still somewhat reduced by deep inspiration. In the subjects with COPD flow rates on PEFV curves were as high or exceeded flow rates on MEFV curves in 76/100 studies; the ratio of flow rates (PEFV)/flow rates (MEFV) increased as pulmonary function worsened; as in normal subjects, Pst,L diminished in COPD subjects following deep inspiration; although flow rates increased on both PEFV and MEFV curves after bronchodilators, the increments in flow were considerably larger on PEFV maneuvers.
通过测量常规肺功能测试以及在总肺容量（TLC）容积历程前后的最大呼气流量容积（MEFV）和部分呼气流量容积（PEFV）曲线以及肺弹性回缩力（Pst，L），对正常对照受试者和慢性阻塞性肺疾病（COPD）患者进行了研究。在正常受试者中：在使用支气管扩张剂之前，气流显著增加，而在吸气至TLC后，Pst，L和上游段阻力（Rus）显著降低；吸入支气管扩张剂后，PEFV曲线上的流速高于MEFV曲线；然而，由于深呼吸后Pst，L大幅下降，深吸气后支气管扩张剂后的Rus仍有所降低。在COPD患者中，在76/100项研究中，PEFV曲线上的流速与MEFV曲线上的流速一样高或超过MEFV曲线上的流速；流速比（PEFV）/流速（MEFV）随着肺功能恶化而增加；与正常受试者一样，COPD患者深吸气后Pst，L减小；尽管支气管扩张剂后PEFV和MEFV曲线上的流速均增加，但PEFV操作时流速的增加幅度要大得多。
