Liu Ming, Sun Xiaojuan
School of Science, Beijing University of Posts and Telecommunications, Beijing, China.
Front Neurosci. 2023 Apr 4;17:1132980. doi: 10.3389/fnins.2023.1132980. eCollection 2023.
Dendrites of fast-spiking basket cells (FS BCs) impact neural circuit functions in brain with both supralinear and sublinear integration strategies. Diverse spatial synaptic inputs and active properties of dendrites lead to distinct neuronal firing patterns. How the FS BCs with this bi-modal dendritic integration respond to different spatial dispersion of synaptic inputs remains unclear. In this study, we construct a multi-compartmental model of FS BC and analyze neuronal firings following simulated synaptic protocols from fully clustered to fully dispersed. Under these stimulation protocols, we find that supralinear dendrites dominate somatic firing of FS BC, while the preference for dispersing is due to sublinear dendrites. Moreover, we find that dendritic diameter and Ca-permeable AMPA conductance play an important role in it, while A-type K channel and NMDA conductance have little effect. The obtained results may give some implications for understanding dendritic computation.
快速放电篮状细胞（FS BCs）的树突通过超线性和亚线性整合策略影响大脑中的神经回路功能。树突多样的空间突触输入和活性特性导致了不同的神经元放电模式。具有这种双模式树突整合的FS BCs如何响应不同空间分布的突触输入仍不清楚。在本研究中，我们构建了FS BC的多房室模型，并分析了在从完全聚集到完全分散的模拟突触协议下的神经元放电情况。在这些刺激协议下，我们发现超线性树突主导了FS BC的体细胞放电，而对分散的偏好则归因于亚线性树突。此外，我们发现树突直径和钙通透性AMPA电导在其中起重要作用，而A型钾通道和NMDA电导影响较小。所得结果可能对理解树突计算有一定启示。
