关于RNA双链体，不同RNA修饰物理性质的理论视角。
A theoretical perspective of the physical properties of different RNA modifications with respect to RNA duplexes.
作者信息
Chiu Norman H L, Simpson Jennifer H, Wang Hongzhou, Tannous Bakhos A
机构信息
Department of Chemistry and Biochemistry, University of North Carolina Greensboro, Greensboro, NC 27402, United States.
Joint School of Nanoscience and Nanoengineering, University of North Carolina Greensboro, Greensboro, NC 27401, United States.
出版信息
BBA Adv. 2021 Sep 22;1:100025. doi: 10.1016/j.bbadva.2021.100025. eCollection 2021.
Epitranscriptomic variations include >140 different RNA modifications, many of which can serve as disease biomarkers. Owing to the challenges on synthesizing modified RNA oligos, majority of earlier studies on the effects of RNA modifications to RNA duplexes focused on selected individual epitranscriptomic variation. There are also limited development on the computational modeling of RNA duplexes containing a specific epitranscriptomic variation. This study aims to theoretically estimate the physical properties of different modified ribonucleosides and compare their variations with respect to altering the molecular structure of an RNA duplex.
表观转录组变异包括140多种不同的RNA修饰，其中许多可作为疾病生物标志物。由于合成修饰RNA寡核苷酸存在挑战，早期关于RNA修饰对RNA双链体影响的研究大多集中在选定的个别表观转录组变异上。对于含有特定表观转录组变异的RNA双链体的计算建模也进展有限。本研究旨在从理论上估计不同修饰核糖核苷的物理性质，并比较它们在改变RNA双链体分子结构方面的差异。
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