Baccaro C, Bennardini F, Dini G, Franconi F, Giotti A, Matucci R, Minuti P
Br J Pharmacol. 1986 Apr;87(4):649-56. doi: 10.1111/j.1476-5381.1986.tb14581.x.
The effect of L-arginine methylester (L-Arg-Me) was studied in the isolated heart of the guinea-pig perfused with hypoxic substrate-free medium for 30 min and subsequently reoxygenated with normal saline solution for 30 min. The administration of L-Arg-Me in basal conditions decreases dose-dependently heart rate without any changes in the myocardial structure. On the other hand, the administration of L-Arg-Me (5-10 mM) decreases ventricular arrhythmias, especially during reoxygenation; in fact ventricular fibrillation is abolished. L-Arg-Me treatment increases the recovery of normal electrical and mechanical activity at the end of reoxygenation and reduces the increase in basal tone. Treatment with 10 mM L-Arg-Me decreases lactate dehydrogenase (LDH) release in the effluent and lysosomal fragility in cardiac tissue, while it does not influence calcium gain. L-Arginine (L-Arg) does not mimic any of the effects of L-Arg-Me.
在豚鼠离体心脏中研究了L-精氨酸甲酯（L-Arg-Me）的作用。将豚鼠离体心脏用缺氧无底物培养基灌注30分钟，随后用生理盐水再灌注30分钟。在基础条件下给予L-Arg-Me可使心率呈剂量依赖性降低，而心肌结构无任何变化。另一方面，给予L-Arg-Me（5-10 mM）可减少室性心律失常，尤其是在再灌注期间；实际上可消除心室颤动。L-Arg-Me处理可增加再灌注结束时正常电活动和机械活动的恢复，并降低基础张力的增加。用10 mM L-Arg-Me处理可减少流出液中乳酸脱氢酶（LDH）的释放以及心脏组织中溶酶体的脆性，而不影响钙摄取。L-精氨酸（L-Arg）不能模拟L-Arg-Me的任何作用。
