牛磺酸对豚鼠心脏在缺氧（无糖条件下）及复氧（有糖条件下）时的保护作用。
The protective effects of taurine on hypoxia (performed in the absence of glucose) and on reoxygenation (in the presence of glucose) in guinea-pig heart.
作者信息
Franconi F, Stendardi I, Failli P, Matucci R, Baccaro C, Montorsi L, Bandinelli R, Giotti A
出版信息
Biochem Pharmacol. 1985 Aug 1;34(15):2611-5. doi: 10.1016/0006-2952(85)90556-8.
PMID:4015703
Abstract
In isolated guinea-pig heart submitted to hypoxia in the absence of substrate and subsequent reoxygenation 1-20 mM taurine decreases LDH release and ventricular arrhythmias, and the recovery of normal electrical and mechanical activity is increased. The taurine effect is dose-dependent, and is not mimicked by beta-alanine. Moreover, taurine reduces the increase in calcium gain of reoxygenated heart.
摘要
在无底物情况下经历缺氧并随后复氧的离体豚鼠心脏中，1 - 20 mM 的牛磺酸可减少乳酸脱氢酶释放和室性心律失常，并增加正常电活动和机械活动的恢复。牛磺酸的作用呈剂量依赖性，且β - 丙氨酸不能模拟其作用。此外，牛磺酸可减少复氧心脏钙摄取的增加。
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